D
Dmitry N. Kaluzhny
Researcher at Engelhardt Institute of Molecular Biology
Publications - 69
Citations - 775
Dmitry N. Kaluzhny is an academic researcher from Engelhardt Institute of Molecular Biology. The author has contributed to research in topics: DNA & Oligonucleotide. The author has an hindex of 14, co-authored 61 publications receiving 630 citations. Previous affiliations of Dmitry N. Kaluzhny include Russian Academy of Sciences.
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Journal ArticleDOI
The expanding repertoire of G4 DNA structures
Anna M. Varizhuk,Dmitry S. Ischenko,Vladimir B. Tsvetkov,Roman A. Novikov,Nikolay A. Kulemin,Dmitry N. Kaluzhny,Maria Vlasenok,Vladimir Naumov,Igor P. Smirnov,Galina E. Pozmogova +9 more
TL;DR: It is suggested that, similar to classical G4s, imperfect G 4s could be considered as potential regulatory elements, pathology biomarkers and therapeutic targets, reflecting the enhanced sequential diversity of these motifs.
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Conformation and thermostability of oligonucleotide d(GGTTGGTGTGGTTGG) containing thiophosphoryl internucleotide bonds at different positions.
M. A. Zaitseva,Dmitry N. Kaluzhny,Anna K. Shchyolkina,Olga F. Borisova,Igor P. Smirnov,Galina E. Pozmogova +5 more
TL;DR: According to the thrombin time test, the aptamer with thio-modifications in both TT loops (LL11) exhibits the same antithrombin efficiency as the original TBA, and shows better stability against DNA nuclease compared to that of TBA.
Journal ArticleDOI
Synthesis, characterization and in vitro activity of thrombin-binding DNA aptamers with triazole internucleotide linkages.
Anna M. Varizhuk,Vladimir B. Tsvetkov,Olga N. Tatarinova,Dmitry N. Kaluzhny,V. L. Florentiev,Edward N. Timofeev,Anna K. Shchyolkina,Olga F. Borisova,Igor P. Smirnov,S. L. Grokhovsky,Anton V. Aseychev,Galina E. Pozmogova +11 more
TL;DR: Due to their relatively high activity and the increased resistance to nuclease digestion imparted by the triazole internucleotide linkages, the novel aptamers are a promising alternative to known DNA-based anticoagulant agents.
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Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties
Andrey E. Shchekotikhin,Lyubov G. Dezhenkova,Vladimir B. Tsvetkov,Yuri N. Luzikov,Yulia L. Volodina,Victor V. Tatarskiy,Anastasia A. Kalinina,Michael I. Treshalin,Helen M. Treshalina,Vladimir I. Romanenko,Dmitry N. Kaluzhny,Michael H.G. Kubbutat,Dominique Schols,Yves Pommier,Alexander A. Shtil,Maria N. Preobrazhenskaya +15 more
TL;DR: 3d demonstrated an antitumor activity in a model of murine intraperitoneally transplanted P388 leukemia, achieving the increase of animal life span up to 262% at tolerable doses, and the 'scaffold hopping' demonstrated its productivity for obtaining new perspective antitumors drug candidates.
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Synthesis of triazole-linked oligonucleotides with high affinity to DNA complements and an analysis of their compatibility with biosystems.
Anna M. Varizhuk,Anna M. Varizhuk,Dmitry N. Kaluzhny,Roman A. Novikov,Alexandr O. Chizhov,Igor P. Smirnov,A. N. Chuvilin,Olga N. Tatarinova,Gleb Y. Fisunov,Galina E. Pozmogova,V. L. Florentiev +10 more
TL;DR: These new oligonucleotide analogues with triazole internucleotide linkages with remote from the 3'-terminus were synthesized and their hybridization properties were studied, suggesting that they are among the most promising Triazole DNA mimics characterized to date.