D
Dmytro O. Minchenko
Researcher at National Academy of Sciences of Ukraine
Publications - 86
Citations - 954
Dmytro O. Minchenko is an academic researcher from National Academy of Sciences of Ukraine. The author has contributed to research in topics: Endoplasmic reticulum & Gene knockdown. The author has an hindex of 12, co-authored 81 publications receiving 810 citations. Previous affiliations of Dmytro O. Minchenko include Bogomolets National Medical University.
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Journal ArticleDOI
Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1α activation
TL;DR: The results indicate that testis‐specific form of PFKFB or PFK‐2/FBPase‐2 is also expressed in several cancer cell lines and that hypoxia induces transcription of PKFB4 gene in these cell lines by HIF‐1α dependent mechanism.
Journal ArticleDOI
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors
Oleksandr H. Minchenko,Atsushi Ochiai,Opentanova Il,Tsutomu Ogura,Dmytro O. Minchenko,Jaime Caro,Serhiy Komisarenko,Hiroyasu Esumi +7 more
TL;DR: Overexpression of PFKFB-4 transcript levels in breast and colon malignant tumors correlates with enhanced expression of PKFB-3, hypoxia-inducible factor (HIF)-1alpha and known HIF-1 dependent genes glucose transporter 1 (Glut1) and vascular endothelial growth factor (VEGF).
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Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.
Anastasiya Y Bobarykina,Dmytro O. Minchenko,Opentanova Il,Michel Moenner,Jaime Caro,Hiroyasu Esumi,Oleksandr H. Minchenko +6 more
TL;DR: Evidence is provided that PFKFB-4 and PFKfb-3 genes are also expressed in gastric and pancreatic cancer cells, they strongly respond to hypoxia via a HIF-1alpha dependent mechanism and, together with the expression of PFK FB-1 and PKFB-2 genes, possibly have a significant role in the Warburg effect which is found in malignant cells.
Journal ArticleDOI
Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells.
Oleksandr H. Minchenko,Katsuya Tsuchihara,Dmytro O. Minchenko,Andreas Bikfalvi,Hiroyasu Esumi +4 more
TL;DR: Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor (VEGF) and Glut1 mRNA as well as with increased level of HIF-1α protein.
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Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.
Oleksandr H. Minchenko,Opentanova Il,Tsutomu Ogura,Dmytro O. Minchenko,Serhiy Komisarenko,Jaime Caro,Hiroyasu Esumi +6 more
TL;DR: Evidence is provided that PFKFB4 gene is also expressed in mammary gland cancer cells and strongly responds to hypoxia via an HIF-1alpha dependent mechanism and the site-specific mutagenesis in the 5'-flanking region of PFK FB4 gene could be limited.