Author
Domenico Cucinotta
Bio: Domenico Cucinotta is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 2156 citations.
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19 Mar 2020
TL;DR: The Director-General of the World Health Organization, Dr. Tedros Adhanom Ghebreyesus, noted that over the past 2 weeks, the number of cases outside China increased 13-fold and theNumber of countries with cases increased threefold, and further increases are expected.
Abstract: The World Health Organization (WHO) on March 11, 2020, has declared the novel coronavirus (COVID-19) outbreak a global pandemic (1). At a news briefing , WHO Director-General, Dr. Tedros Adhanom Ghebreyesus, noted that over the past 2 weeks, the number of cases outside China increased 13-fold and the number of countries with cases increased threefold. Further increases are expected. He said that the WHO is "deeply concerned both by the alarming levels of spread and severity and by the alarming levels of inaction," and he called on countries to take action now to contain the virus. "We should double down," he said. "We should be more aggressive." [...].
4,415 citations
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TL;DR: In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients, and Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesavir therapy.
Abstract: Background Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2. Methods We provided remdesivir on a compassionate-...
2,314 citations
TL;DR: At least a subset of sustained, severe COVID-19 may define a type of catastrophic microvascular injury syndrome mediated by activation of complement pathways and an associated procoagulant state, and could suggest targets for specific intervention.
1,787 citations
21 Jun 2020
TL;DR: In this paper, a study examines the attitudes of Pakistani higher education students towards online education in underdeveloped countries like Pakistan, where a vast majority of students are unable to access the internet due to technical as well as monetary issues.
Abstract: This research study examines the attitudes of Pakistani higher education students towards compulsory digital and distance learning university courses amid Coronavirus (COVID-19). Undergraduate and postgraduate were surveyed to find their perspectives about online education in Pakistan. The findings of the study highlighted that online learning cannot produce desired results in underdeveloped countries like Pakistan, where a vast majority of students are unable to access the internet due to technical as well as monetary issues. The lack of face-to-face interaction with the instructor, response time and absence of traditional classroom socialization were among some other issues highlighted by higher education students.
987 citations
Hospital General Universitario Gregorio Marañón1, King's College London2, South London and Maudsley NHS Foundation Trust3, Seconda Università degli Studi di Napoli4, University of Copenhagen5, Pontifical Catholic University of Chile6, University of South Florida7, Royal College of Surgeons in Ireland8, Hofstra University9, Charité10, Yale University11, RMIT University12, University of Birmingham13, University of Hong Kong14, University of Paris15, University College London16, Nanyang Technological University17, Columbia University18, University of Antioquia19, Katholieke Universiteit Leuven20, Shanghai Jiao Tong University21, Keio University22, University of Barcelona23, University of Brescia24
TL;DR: The interconnectedness of the world made society vulnerable to this infection, but it also provides the infrastructure to address previous system failings by disseminating good practices that can result in sustained, efficient, and equitable delivery of mental health-care delivery.
958 citations
TL;DR: At 35 days, NVX-CoV2373 appeared to be safe, and it elicited immune responses that exceeded levels in Covid-19 convalescent serum, and the addition of adjuvant resulted in enhanced immune responses, was antigen dose–sparing, and induced a T helper 1 (Th1) response.
Abstract: Background NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins a...
930 citations