D
Dominika Truban
Researcher at Mayo Clinic
Publications - 4
Citations - 362
Dominika Truban is an academic researcher from Mayo Clinic. The author has contributed to research in topics: PINK1 & Parkin. The author has an hindex of 3, co-authored 4 publications receiving 274 citations.
Papers
More filters
Journal ArticleDOI
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
TL;DR: This review summarizes the latest findings on PINK1/Parkin-directed mitochondrial quality control, its integration and cross-talk with other disease factors and pathways as well as the implications for idiopathic PD.
Journal ArticleDOI
Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism
Andreas Puschmann,Fabienne C. Fiesel,Thomas R. Caulfield,Roman Hudec,Maya Ando,Dominika Truban,Xu Hou,Kotaro Ogaki,Michael G. Heckman,Elle D. James,Maria Swanberg,Itzia Jimenez-Ferrer,Oskar Hansson,Grzegorz Opala,Joanna Siuda,Magdalena Boczarska-Jedynak,Andrzej Friedman,Dariusz Koziorowski,Monika Rudzińska-Bar,Jan O. Aasly,Timothy Lynch,George D. Mellick,Megha Mohan,Peter A. Silburn,Peter A. Silburn,Y Sanotsky,Carles Vilariño-Güell,Carles Vilariño-Güell,Matthew J. Farrer,Matthew J. Farrer,Li Chen,Valina L. Dawson,Ted M. Dawson,Zbigniew K. Wszolek,Owen A. Ross,Owen A. Ross,Wolfdieter Springer +36 more
TL;DR: Based on genetic and clinical evaluation as well as functional and structural characterization, the p.G411S mutation interferes with ubiquitin phosphorylation by wild-type PINK1 in a heterodimeric complex and impairs the protective functions of the Pink1/parkin-mediated mitochondrial quality control.
Journal ArticleDOI
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease
Xu Hou,Fabienne C. Fiesel,Dominika Truban,Monica Castanedes Casey,Wen Lang Lin,Alexandra I. Soto,Pawel Tacik,Linda Rousseau,Nancy N. Diehl,Michael G. Heckman,Oswaldo Lorenzo-Betancor,Isidre Ferrer,José Matías Arbelo,John C. Steele,Matthew J. Farrer,Mario Cornejo-Olivas,Luis Torres,Ignacio F. Mata,Neill R. Graff-Radford,Zbigniew K. Wszolek,Owen A. Ross,Melissa E. Murray,Dennis W. Dickson,Wolfdieter Springer +23 more
TL;DR: This study provides further evidence for a potential pathogenic overlap among different forms of PD and suggests that p-S65-Ub can serve as a biomarker for mitochondrial damage in aging and disease.
Journal ArticleDOI
Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder
Andreas Puschmann,Fabienne C. Fiesel,Thomas R. Caulfield,Roman Hudec,Maya Ando,Dominika Truban,Xu Hou,Kotaro Ogaki,Michael G. Heckman,Elle D. James,Maria Swanberg,Itzia Jimenez-Ferrer,Oskar Hansson,Grzegorz Opala,Joanna Siuda,Magdalena Boczarska-Jedynak,Andrzej Friedman,Dariusz Koziorowski,Monika Rudzińska-Bar,Jan O. Aasly,Timothy Lynch,George D. Mellick,Megha Mohan,Peter A. Silburn,Peter A. Silburn,Y Sanotsky,Carles Vilariño-Güell,Carles Vilariño-Güell,Matthew J. Farrer,Matthew J. Farrer,Li Chen,Valina L. Dawson,Ted M. Dawson,Zbigniew K. Wszolek,Owen A. Ross,Owen A. Ross,Wolfdieter Springer +36 more
TL;DR: Gan-Or et al. as mentioned in this paper showed that the PINK1 p.G411S mutation confers a marked increase in Parkinson's disease risk odds ratio = 2.89, P = 0.027.