Dominique Perrin

TL;DR: It is shown that Pik3cg−/− mice are largely protected in mouse models of rheumatoid arthritis; this protection correlates with defective neutrophil migration, further validating PI3Kγ as a therapeutic target.

TL;DR: A novel series of furan-2-ylmethylene thiazolidinediones as selective, ATP-competitive PI3Kgamma inhibitors are disclosed and Compound 26 (AS-252424), a potent and selective small-molecule PI3kgamma inhibitor emerging from these efforts, was further profiled in three different cellular PI 3K assays and shown to be selective for class IB PI2K-mediated cellular effects.

TL;DR: The results suggest that AS057278 has the potential to anti-psychotic action toward both cognitive and positive symptoms of schizophrenia.

TL;DR: The development of a potent, selective inhibitor of Mycobacterium tuberculosis PtpB, a bacterial PTP that is secreted into host cells where it disrupts unidentified signaling pathways is reported.

TL;DR: F 11782, a novel epipodophylloid, proved a potent inhibitor of the catalytic activities of both topoisomerases I and II with an original mechanism of action, and may be considered to represent the first of a new class of topoisomersase-interacting agents.