https://mysite.science.uottawa.ca/rsmith43/MAT4996/GranichGilks.pdf

Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)60886-7.pdf

Behavioural strategies to reduce HIV transmission: how to make them work better

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)61404-X.pdf

Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care

An assessment of interactions between global health initiatives and country health systems

Background: Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, the most urgent requirement includes the improvement of HIV (Human Immunodeficiency Virus) prevention and sexual transmission and the development of new drugs to treat the chronic lifelong infection. Methods: Six chloro-1,4-dimethyl-9H-carbazoles (2a,b–4a,b) have been prepared following opportunely modified known chemical procedures and tested in luciferase and Escherichia coli β-galactosidase expressing CD4+, CXCR4+, CCR5+ TZM-bl cells. Results and Conclusion: a preliminary biological investigation on the synthesized small series of chloro-1,4-dimethyl-9H-carbazoles has been carried out. Among all tested compounds, a nitro-derivative (3b) showed the most interesting profile representing a suitable lead for the development of novel anti-HIV drugs.

Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(06)69158-7.pdf

The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings

Uganda is one of only two countries in the world that has successfully reversed the course of its HIV epidemic. There remains much controversy about how Uganda's HIV prevalence declined in the 1990s. This article describes the prevention programs and activities that were implemented in Uganda during critical years in its HIV epidemic, 1987 to 1994. Multiple resources were aggregated to fuel HV prevention campaigns at multiple levels to a far greater degree than in neighboring countries. We conclude that the reversed direction of the HIV epidemic in Uganda was the direct result of these interventions and that other countries in the developing world could similarly prevent or reverse the escalation of HIV epidemics with greater availability of HIV prevention resources, and well designed programs that take efforts to a critical breadth and depth of effort.

/pdf/how-uganda-reversed-its-hiv-epidemic-2g02tmx9b1.pdf

Don Sutherland

Papers

The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings

How Uganda reversed its HIV epidemic.