D
Donald G. McEwen
Researcher at University of Texas Health Science Center at San Antonio
Publications - 23
Citations - 5328
Donald G. McEwen is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Fibroblast growth factor & Wnt signaling pathway. The author has an hindex of 19, co-authored 23 publications receiving 5048 citations. Previous affiliations of Donald G. McEwen include University of North Carolina at Chapel Hill & Washington University in St. Louis.
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Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.
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Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut
Huaqi Jiang,Parthive H. Patel,Alexander Kohlmaier,Marc O. Grenley,Donald G. McEwen,Bruce A. Edgar +5 more
TL;DR: It is shown that when enterocytes in the Drosophila midgut are subjected to apoptosis, enteric infection, or JNK-mediated stress signaling, they produce cytokines that activate Jak/Stat signaling in ISCs, promoting their rapid division and enabling stem cells to replace spent progeny as they are lost, thereby establishing gut homeostasis.
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Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.
TL;DR: It is demonstrated that Fgfr3 is essential for normal endochondral ossification and inner ear development and Contrasts between the skeletal phenotype and achondroplasia suggest that activation of FGFR3 causes achondaplasia.
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Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1.
TL;DR: It is demonstrated both by binding studies on genetically engineered soluble receptors and by the mitogenic response of growth factor-dependent cell lines that this splice variant of FGFR3 (FGFR3 IIIb), by binding only acidic FGF (aFGF/FGF-1), has the most restricted ligand binding properties of any FGFR thus far described.
Journal ArticleDOI
Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis
Donald G. McEwen,Mark Peifer +1 more
TL;DR: In this paper, the function of Puckered (Puc), the sole Drosophila Jun N-terminal protein (JNK)-specific MAPK, during embryonic and imaginal disc development was investigated.