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Showing papers by "Donald Maxwell Parkin published in 1992"


Journal ArticleDOI
TL;DR: Incidence was generally higher in regions and among ethnic groups enjoying a higher standard of living, though previous studies within single countries had suggested that neuroblastoma is more common among less affluent groups.
Abstract: The International Agency for Research on Cancer has coordinated a worldwide study of childhood cancer incidence, with data from over 50 countries. We present here the results for neuroblastoma. In predominantly white Caucasian populations the age-standardized rate was 7-12 per million, and 6-10% of all childhood cancers were neuroblastomas. Rates were highest in the first year of life (25-50 per million, 30% of total neuroblastoma incidence), and decreased with age to 15-20 per million (50% of the total) at age 1-4, 2-4 per million (15%) at 5-9 and 1-1.5 per million (5%) at 10-14. In the United States, black children had an incidence of 8.5 per million compared with 11.5 among Whites; Blacks tended to be older than Whites at diagnosis. The highest rate in Africa was in Bulawayo, Zimbabwe (8.0 per million) and the lowest in West Nile, Uganda, with no cases registered. Incidence in Israel was similar to that in many white populations, with Jews having a particularly high rate. In other parts of West Asia neuroblastoma had a low relative frequency, suggesting that incidence is low. Rates were also low throughout much of southern and eastern Asia, including India and China. Incidence in Japan was somewhat higher, though less than in Western countries, with the deficit most pronounced in the first year of life; these data relate to the period before mass screening of infants for neuroblastoma in the regions concerned. Incidence was generally higher in regions and among ethnic groups enjoying a higher standard of living, though previous studies within single countries had suggested that neuroblastoma is more common among less affluent groups. Blacks in Africa and the United States may have a weaker genetic predisposition to neuroblastoma, but some of the deficit in many developing countries is likely to be due to under-diagnosis.

126 citations


Journal Article
TL;DR: Comparing cancer risk in the Polish-born population of France and in native French subjects (born in France), using mortality data from the period 1979-1985, shows that Polish migrants retain their characteristically high rates of cancer of the stomach and lung, and low rates of breast and prostate cancer.
Abstract: Cancer risk in the Polish-born population of France has been compared to that in Poland and in native French subjects (born in France), using mortality data from the period 1979-1985. The Polish-born community in France is a long-established one--most migration occurred during the 1920s--so that for many cancer sites the cancer pattern is closer to that of French natives than that in Poland (eg oral cavity, oesophagus, large bowel, gall bladder, uterus, leukaemia). Polish migrants, however, retain their characteristically high rates of cancer of the stomach and lung (in men), and low rates of breast and prostate cancer. The Polish-born community has a characteristic pattern of residence (living mainly in the Nord and the Pas-de-Calais) and occupational status (a higher proportion of 'workers' than the French-born); these are important confounding factors which can mask the true differences in risk for several sites (larynx, oesophagus, large bowel) if no adjustment is made during analysis.

9 citations