BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

The field of chemical sensing is becoming ever more dependent upon novel materials. Polymers, crystals, glasses, particles, and nanostructures have made a profound impact and have endowed modern sensory systems with superior performance. Electronic polymers have emerged as one of the most important classes of transduction materials; they readily transform a chemical signal into an easily measured electrical or optical event. Although our group reviewed this field in 2000,1 the high levels of activity and the impact of these methods now justify a subsequent review as part of this special issue. In this review we restrict our discussions to purely fluorescence-based methods using conjugated polymers (CPs). We further confine our detailed coverage to articles published since our previous review and will only detail earlier research in this Introduction to illustrate fundamental concepts and terminology that underpin the recent literature.

Chemical sensors based on amplifying fluorescent conjugated polymers.

There is an enormous demand for chemical sensors for many areas and disciplines. High sensitivity and ease of operation are two main issues for sensor development. Fluorescence techniques can easily fulfill these requirements and therefore fluorescent-based sensors appear as one of the most promising candidates for chemical sensing. However, the development of sensors is not trivial; material science, molecular recognition and device implementation are some of the aspects that play a role in the design of sensors. The development of fluorescent sensing materials is increasingly captivating the attention of the scientists because its implementation as a truly sensory system is straightforward. This critical review shows the use of polymers, sol–gels, mesoporous materials, surfactant aggregates, quantum dots, and glass or gold surfaces, combined with different chemical approaches for the development of fluorescent sensing materials. Representative examples have been selected and they are commented here.

/pdf/design-of-fluorescent-materials-for-chemical-sensing-3qfe7gr6p7.pdf

Design of fluorescent materials for chemical sensing

Semiconductors for organic transistors

A series of rigid microporous poly(aryleneethynylene) (PAE) networks was synthesized by Sonogashira−Hagihara coupling chemistry. PAEs with apparent Brunauer−Emmet−Teller surface areas of more than 1000 m2/g were produced. The materials were found to have very good chemical and thermal stability and retention of microporosity under a variety of conditions. It was shown that physical properties such as micropore size, surface area, and hydrogen uptake could be controlled in a “quantized” fashion by varying the monomer strut length, as for metal−organic and covalent organic frameworks, even though the networks were amorphous in nature. For the first time, it was demonstrated that these properties can also be fine-tuned in a continuous manner via statistical copolymerization of monomer struts with differing lengths. This provides an unprecedented degree of direct synthetic control over micropore properties in an organic network.

Synthetic Control of the Pore Dimension and Surface Area in Conjugated Microporous Polymer and Copolymer Networks

The study of metabolic responses to drugs, environmental changes, and diseases is a new promising area of metabonomic research. Metabolic fingerprints can be obtained by analytical techniques such as nuclear magnetic resonance (NMR). In principle, alterations of these fingerprints due to appearance/disappearance or concentration changes of metabolites can provide early evidences of, for example, onset of diseases. A major drawback in this approach is the strong day-to-day variability of the individual metabolic fingerprint, which should be rather called a metabolic “snapshot.” We show here that a thorough statistical analysis performed on NMR spectra of human urine samples reveals an invariant part characteristic of each person, which can be extracted from the analysis of multiple samples of each single subject. This finding (i) provides evidence that individual metabolic phenotypes may exist and (ii) opens new perspectives to metabonomic studies, based on the possibility of eliminating the daily “noise” by multiple sample collection.

https://www.pnas.org/content/pnas/105/5/1420.full.pdf

Evidence of different metabolic phenotypes in humans

Ultrasonic pulse velocity for the evaluation of physical and mechanical properties of a highly porous building limestone.

Novel multifunctional coatings with photocatalytic and hydrophobic properties for the preservation of the stone building heritage

Synthesis of poly(aryleneethynylene)s bearing glucose units as substituents

2,5-Dialkoxypoly(p-phenyleneethynylene) (3) functionalized with N-t-BOC-l-phenylalanine molecules was synthesized by Pd-catalyzed reaction of dioctyloxybis[(trimethylsilyl)ethynyl]benzene (1) with aromatic diiodide 2 linked to two amino acid units by six carbon atoms alkoxy chains. Optical properties were investigated both in solution and in the solid state (as thin films) by absorption, fluorescence and chiroptical spectroscopies (CD and CPL). Polymer 3, that represents one of few fully characterized dialkoxy-substituted PAEs, is also the first example of a poly(aryleneethynylene) (PAE) with amino acidic chiral pendants.

Donato Colangiuli

Papers

Evidence of different metabolic phenotypes in humans

Ultrasonic pulse velocity for the evaluation of physical and mechanical properties of a highly porous building limestone.

Novel multifunctional coatings with photocatalytic and hydrophobic properties for the preservation of the stone building heritage

Synthesis of poly(aryleneethynylene)s bearing glucose units as substituents

Synthesis and Chiroptical Characterization of an Amino Acid Functionalized Dialkoxypoly(p-phenyleneethynylene)