Dong Fang

TL;DR: Results indicate that H3.3K27M mutation reprograms epigenetic landscape and gene expression, which may drive tumorigenesis.

TL;DR: It is shown that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K 27M cells and in vivo against K27m xenografts.

TL;DR: It is shown that H3K36 methylation is reduced globally in human chondroblastomas and inchondrocytes harboring the same genetic mutation, due to inhibition of at least two H3 K36 methyltransferases, MMSET and SETD2, by the H3.3K 36M mutant proteins.

TL;DR: An enhancer is identified between the promoters of MKI67 and MGMT, that when activated drives MGMT expression despite MGMT promoter methylation to confer TMZ resistance in GBM, uncovering a mechanism that regulates MG MT expression, confers TMZ resistance, and potentially regulates tumor proliferation.

TL;DR: This chapter focuses on the general introductions of epigenetics, which is important in the regulation of chromatin structure and gene expression, and various mutations of epigenetic regulators have been identified and proven to be the drivers of tumorigenesis.