D
Dong Sung An
Researcher at University of California, Los Angeles
Publications - 52
Citations - 5479
Dong Sung An is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Haematopoiesis & Small hairpin RNA. The author has an hindex of 37, co-authored 52 publications receiving 5000 citations.
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Journal ArticleDOI
Lentivirus-delivered stable gene silencing by RNAi in primary cells.
Sheila A. Stewart,Derek M. Dykxhoorn,Deborah Palliser,Hana Mizuno,Evan Y. Yu,Dong Sung An,David M. Sabatini,Irvin S. Y. Chen,William C. Hahn,Phillip A. Sharp,Robert A. Weinberg,Carl D. Novina +11 more
TL;DR: It is demonstrated that both Moloney leukemia virus and lentivirus vector-mediated expression of RNAi can achieve effective, stable gene silencing in diverse biological systems and will assist in elucidating gene functions in numerous cell types including primary cells.
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Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
TL;DR: The studies demonstrate the feasibility and potential of lentiviral vector-mediated delivery of siRNAs as a general means of intracellular immunization for the treatment of HIV-1 and other viral diseases.
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Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
Alejandro B. Balazs,Yong Ouyang,Christin M. Hong,Christin M. Hong,Joyce Chen,Steven M Nguyen,Dinesh S. Rao,Dong Sung An,David Baltimore +8 more
TL;DR: It is demonstrated that VIP is capable of protecting humanized mice from intravenous as well as vaginal challenge with diverse HIV strains despite repeated exposures, suggesting that VIP may be effective in preventing vaginal transmission of HIV between humans.
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The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.
Sonal Srikanth,Jin Seok Woo,Beibei Wu,Yasser M. El-Sherbiny,Yasser M. El-Sherbiny,Yasser M. El-Sherbiny,Jennifer Leung,Koollawat Chupradit,Laura Rice,Gil Ju Seo,Guillaume Calmettes,Chandran Ramakrishna,Edouard M. Cantin,Dong Sung An,Ren Sun,Ting-Ting Wu,Jae U. Jung,Sinisa Savic,Sinisa Savic,Yousang Gwack +19 more
TL;DR: It is found that deficiency in the Ca2+ sensor stromal interaction molecule 1 (STIM1) caused spontaneous activation of STING and enhanced expression of type I interferons under resting conditions in mice and a patient with combined immunodeficiency.
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Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.
Dong Sung An,Robert E. Donahue,Masakazu Kamata,Betty Poon,Mark E. Metzger,Si-Hua Mao,Aylin C. Bonifacino,Allen E. Krouse,Jean-Luc Darlix,David Baltimore,F. Xiao-Feng Qin,Irvin S. Y. Chen +11 more
TL;DR: These studies provide a successful demonstration that siRNAs can be used together with hematopoietic stem cell transplant to stably modulate gene expression in primates and potentially treat blood diseases such as HIV-1.