Dong Wang

Bio: Dong Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Scanning tunneling microscope & Medicine. The author has an hindex of 49, co-authored 491 publications receiving 9970 citations. Previous affiliations of Dong Wang include University of Science and Technology of China & Shanghai University.

Copper(II)-catalyzed highly regio- and stereo-selective hydrosilylation of unactivated internal alkynes with silylborate in water.

Abstract: The highly regio- and stereoselective hydrosilylation of internal alkynes with silylborate catalyzed by Cu(OTf)2 with 1,10-phenanthroline as the ligand in the presence of Cs2CO3 in water is developed. This protocol was applied efficiently in the aqueous synthesis of multi-substituted vinylsilanes.

MicroRNAs in Drug-induced Liver Injury.

Abstract: Drug-induced liver injury (DILI) is a leading cause of acute liver failure, and a major reason for the recall of marketed drugs. Detection of potential liver injury is a challenge for clinical management and preclinical drug safety studies, as well as a great obstacle to the development of new, effective and safe drugs. Currently, serum levels of alanine and aspartate aminotransferases are the gold standard for evaluating liver injury. However, these levels are assessed by nonspecific, insensitive, and non-predictive tests, and often result in false-positive results. Therefore, there is an urgent need for better DILI biomarkers to guide risk assessment and patient management. The discovery of microRNAs (miRNAs) as a new class of gene expression regulators has triggered an explosion of research, particularly on the measurement of miRNAs in various body fluids as biomarkers for many human diseases. The properties of miRNA-based biomarkers, such as tissue specificity and high stability and sensitivity, suggest they could be used as novel, minimally invasive and stable DILI biomarkers. In the current review, we summarize recent progress concerning the role of miRNAs in diagnosing and monitoring both clinical and preclinical DILI, and discuss the main advantages and challenges of miRNAs as novel DILI biomarkers.

Effect of exciplex formation on organic light emitting diodes based on rare-earth complex

Abstract: An exciplex can be formed due to the charge transfer between the lowest unoccupied molecular orbital (LUMO) of the acceptor and the highest occupied molecular orbital (HOMO) of the donor. By introducing a mixing layer composed of [N,N′-diphenyl-N,N′bis (3-methylphenyl)-1,1′-diphenyl-4,4′-diamine] (TPD) and europium(dibenzoylmethanato)3(bathophenanthroline) [Eu(DBM)3bath] and a graded interface, elimination of light emission from the exciplex and significant luminescence enhancement of trivalent europium ions (Eu3+) in organic light emitting devices have been achieved. The elimination mechanism of exciplex emission based on the concept that an exciplex can be formed between LUMO of the acceptor (Eu complex) and HOMO of donor (TPD) was investigated. To comprehensively understand the mechanism, devices consisting of a Eu(DBM)3bath as the emitting material and the devices using other rare-earth (RE) complex [RE(DBM)3bath] as the emitting material were fabricated with the same device configuration. As a refere...

Hollow double-layer carbon nanocage confined Si nanoparticles for high performance lithium-ion batteries

Abstract: The huge volume variation and the unstable solid electrolyte interface (SEI) of Si (Si) during the lithiation and delithiation process severely obstruct its practical application as lithium-ion battery anodes. Here, we design and fabricate a hollow structure of double-layer hybrid carbon nanocage encapsulated Si nanoparticles to address these challenges. The double-layer hybrid carbon-Si nanoarchitecture is obtained by integrating electrostatic self-assembly, seed-induced growth and heterogeneous shrinkage. The internal layer of hollow N-doped carbon of the hybrid nanoarchitecture (Si@H-NC@GC) provides limited inner space for controlling volume changes of Si nanoparticles, while the outer graphite carbon layer facilitates the formation of a stable SEI. When evaluated as anode materials for LIBs, the Si@H-NC@GC nanoarchitecture exhibits greatly enhanced electrochemical performance compared with the bare Si, Si@NC and H-NC@GC electrodes. Notably, Si@H-NC@GC delivers a reversible capacity retention of 92.5% after 550 cycles at a high current density of 1 A g−1 and a high capacity of 1081 mA h g−1 after 500 cycles at 0.5 A g−1.

Fabrication of bilayer tetrathiafulvalene integrated surface covalent organic frameworks

Abstract: A bilayer covalent organic framework (COF) of TTF-based building blocks was obtained by imine reaction between tetrathiafulvalene tetraaldehyde (4ATTF) and p-phenylenediamine (PPDA). Direct evidence for the eclipsed stacking of bilayer structure via π–π interaction between TTF units is provided by high resolution scanning tunneling microscopy.

Shedding light on the cell biology of extracellular vesicles.

Abstract: Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively They are present in biological fluids and are involved in multiple physiological and pathological processes Extracellular vesicles are now considered as an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids and genetic material Knowledge of the cellular processes that govern extracellular vesicle biology is essential to shed light on the physiological and pathological functions of these vesicles as well as on clinical applications involving their use and/or analysis However, in this expanding field, much remains unknown regarding the origin, biogenesis, secretion, targeting and fate of these vesicles

Toward Safe Lithium Metal Anode in Rechargeable Batteries: A Review.

Abstract: The lithium metal battery is strongly considered to be one of the most promising candidates for high-energy-density energy storage devices in our modern and technology-based society. However, uncontrollable lithium dendrite growth induces poor cycling efficiency and severe safety concerns, dragging lithium metal batteries out of practical applications. This review presents a comprehensive overview of the lithium metal anode and its dendritic lithium growth. First, the working principles and technical challenges of a lithium metal anode are underscored. Specific attention is paid to the mechanistic understandings and quantitative models for solid electrolyte interphase (SEI) formation, lithium dendrite nucleation, and growth. On the basis of previous theoretical understanding and analysis, recently proposed strategies to suppress dendrite growth of lithium metal anode and some other metal anodes are reviewed. A section dedicated to the potential of full-cell lithium metal batteries for practical applicatio...

Recent Advances in Ultrathin Two-Dimensional Nanomaterials

Abstract: Since the discovery of mechanically exfoliated graphene in 2004, research on ultrathin two-dimensional (2D) nanomaterials has grown exponentially in the fields of condensed matter physics, material science, chemistry, and nanotechnology. Highlighting their compelling physical, chemical, electronic, and optical properties, as well as their various potential applications, in this Review, we summarize the state-of-art progress on the ultrathin 2D nanomaterials with a particular emphasis on their recent advances. First, we introduce the unique advances on ultrathin 2D nanomaterials, followed by the description of their composition and crystal structures. The assortments of their synthetic methods are then summarized, including insights on their advantages and limitations, alongside some recommendations on suitable characterization techniques. We also discuss in detail the utilization of these ultrathin 2D nanomaterials for wide ranges of potential applications among the electronics/optoelectronics, electrocat...

Active sites of nitrogen-doped carbon materials for oxygen reduction reaction clarified using model catalysts

Abstract: Nitrogen (N)-doped carbon materials exhibit high electrocatalytic activity for the oxygen reduction reaction (ORR), which is essential for several renewable energy systems. However, the ORR active site (or sites) is unclear, which retards further developments of high-performance catalysts. Here, we characterized the ORR active site by using newly designed graphite (highly oriented pyrolitic graphite) model catalysts with well-defined π conjugation and well-controlled doping of N species. The ORR active site is created by pyridinic N. Carbon dioxide adsorption experiments indicated that pyridinic N also creates Lewis basic sites. The specific activities per pyridinic N in the HOPG model catalysts are comparable with those of N-doped graphene powder catalysts. Thus, the ORR active sites in N-doped carbon materials are carbon atoms with Lewis basicity next to pyridinic N.

Recent Advances in Electrocatalysts for Oxygen Reduction Reaction

Abstract: The recent advances in electrocatalysis for oxygen reduction reaction (ORR) for proton exchange membrane fuel cells (PEMFCs) are thoroughly reviewed. This comprehensive Review focuses on the low- and non-platinum electrocatalysts including advanced platinum alloys, core–shell structures, palladium-based catalysts, metal oxides and chalcogenides, carbon-based non-noble metal catalysts, and metal-free catalysts. The recent development of ORR electrocatalysts with novel structures and compositions is highlighted. The understandings of the correlation between the activity and the shape, size, composition, and synthesis method are summarized. For the carbon-based materials, their performance and stability in fuel cells and comparisons with those of platinum are documented. The research directions as well as perspectives on the further development of more active and less expensive electrocatalysts are provided.