D
Dong-Ya Zhu
Researcher at Nanjing Medical University
Publications - 22
Citations - 1840
Dong-Ya Zhu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Dentate gyrus & Neurogenesis. The author has an hindex of 15, co-authored 22 publications receiving 1641 citations. Previous affiliations of Dong-Ya Zhu include University of Calgary.
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Journal ArticleDOI
Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95
Li Zhou,Fei Li,Hai-Bing Xu,Chun-Xia Luo,Hai-Yin Wu,Ming-Mei Zhu,Wei Lu,Xing Ji,Qi-Gang Zhou,Dong-Ya Zhu +9 more
TL;DR: This drug blocked the ischemia-induced nNOS–PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion and reperfusion.
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ADAR2-Dependent RNA Editing of AMPA Receptor Subunit GluR2 Determines Vulnerability of Neurons in Forebrain Ischemia
Peter L. Peng,Xiafen Zhong,Weihong Tu,Mangala M. Soundarapandian,Peter Molner,Dong-Ya Zhu,Lorraine Lau,Shu Hong Liu,Fang Liu,Youming Lu +9 more
TL;DR: It is shown that forebrain ischemia in adult rats selectively reduces expression of ADAR2 enzyme and, hence, disrupts RNA Q/R site editing of GluR2 subunit in vulnerable neurons, which determines vulnerability of neurons in the rat hippocampus to fore brain ischemic insult.
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Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus.
TL;DR: It is shown that 7 d after focal cerebral ischemia, newly divided cells in the dentate gyrus of adult rats increased to approximately sevenfold, compared with sham controls, and activation of inducible nitric oxide synthase (iNOS) was associated with enhanced dentate neurogenesis.
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Expression of Ca2+-Permeable AMPA Receptor Channels Primes Cell Death in Transient Forebrain Ischemia
Shu Hong Liu,Lorraine Lau,JianShe Wei,Dong-Ya Zhu,Shengwei Zou,Hong-Suo Sun,YangPing Fu,Fang Liu,Youming Lu +8 more
TL;DR: The induction of Ca( 2+) and/or Zn(2+) influx through AMPA receptors by expressing functional Ca(2+)-permeable GluR2(Q) channels causes the postischemic degeneration of hippocampal granule neurons that otherwise are insensitive to ischemic insult.
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Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus.
TL;DR: The findings provide roles and regulatory mechanisms for CREB in adult neurogenesis and possibly suggest a practical strategy for replacing dead neurons in brain injury.