Dongming Xing

TL;DR: It is shown that PKM2 directly binds to histone H3 and phosphorylates hist one H3 at T11 upon EGF receptor activation and this phosphorylation is required for the dissociation of HDAC3 from the CCND1 and MYC promoter regions and subsequent acetylation of histoneH3 at K9.

TL;DR: The findings reveal an important mechanism of histone modification and demonstrate that local generation of succinyl-CoA by the nuclear α-KGDH complex coupled with the succinyltransferase activity of KAT2A is instrumental in histone succinylation, tumour cell proliferation, and tumour development.

TL;DR: This study presents a novel probabilistic procedure called a “navel-gauging” procedure that allows for real-time measurement of the activity of the immune system during the development of cancerous cells.

TL;DR: In this article, the authors summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism.

TL;DR: Activated AKT in human hepatocellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90, which highlights the importance of the protein kinase activity of PCK1 in the activation of SREBPs, lipogenesis and the development of HCC.