Author
Dongxue Fei
Bio: Dongxue Fei is an academic researcher from Northeast Forestry University. The author has contributed to research in topics: Oxidative stress & Arsenic trioxide. The author has an hindex of 8, co-authored 11 publications receiving 203 citations.
Papers
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TL;DR: It is reported that miR-122, the most enriched constitutive miRNA in the liver, induced cell protective autophagy in arsenite-exposed hepatocytes and may be a potential candidate in the treatment of arseniasis.
83 citations
TL;DR: The interaction of divalent zinc ion (Zn2+), an efficient reactive oxygen species (ROS) scavenger with arsenite in the heart of common carp is explored, and the application of zinc preparations may provide a candidate for the prevention and treatment for arsenic poisoning.
71 citations
TL;DR: The results highlighted the need to take precautions against copper and arsenic co-exposure when considering their impact in susceptible animals/populations and can function independently or cooperatively to affect oxidative stress, mitochondrial dynamics and programmed cell death.
35 citations
TL;DR: The results unambiguously suggested that under arsenic stress, zinc can partly relieve intestinal inflammation and disruption of tight junction segment-dependently.
25 citations
TL;DR: The results suggest that As or/and Cu aggravate mitochondrial dysfunction, apoptosis and autophagy in a time-dependent manner, and the combined toxicity of As and Cu was higher.
18 citations
Cited by
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01 Jan 2012
TL;DR: In this article, the associations of metabolites with insulin resistance were studied in 7,098 young Finns (age 31 ± 3 years; 52% women) to elucidate underlying metabolic pathways, using regression models adjusted for age, waist, and standard lipids.
Abstract: Metabolite associations with insulin resistance were studied in 7,098 young Finns (age 31 ± 3 years; 52% women) to elucidate underlying metabolic pathways. Insulin resistance was assessed by the homeostasis model (HOMA-IR) and circulating metabolites quantified by high-throughput nuclear magnetic resonance spectroscopy in two population-based cohorts. Associations were analyzed using regression models adjusted for age, waist, and standard lipids. Branched-chain and aromatic amino acids, gluconeogenesis intermediates, ketone bodies, and fatty acid composition and saturation were associated with HOMA-IR (P < 0.0005 for 20 metabolite measures). Leu, Ile, Val, and Tyr displayed sex- and obesity-dependent interactions, with associations being significant for women only if they were abdominally obese. Origins of fasting metabolite levels were studied with dietary and physical activity data. Here, protein energy intake was associated with Val, Phe, Tyr, and Gln but not insulin resistance index. We further tested if 12 genetic variants regulating the metabolites also contributed to insulin resistance. The genetic determinants of metabolite levels were not associated with HOMA-IR, with the exception of a variant in GCKR associated with 12 metabolites, including amino acids (P < 0.0005). Nonetheless, metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints.
230 citations
TL;DR: An effort has been made to decipher the interplay among heavy metals/metalloids exposures, oxidative stress, and signal transduction, which are essential to mount the cellular and organismal response.
213 citations
05 Feb 2020
TL;DR: The pathways involved in arsenic-induced redox imbalance are detailed, as well as current studies on prophylaxis and treatment strategies using antioxidants.
Abstract: Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been associated with the development of a wide range of diseases and health problems in humans. Arsenic exposure induces the generation of intracellular reactive oxygen species (ROS), which mediate multiple changes to cell behavior by altering signaling pathways and epigenetic modifications, or cause direct oxidative damage to molecules. Antioxidants with the potential to reduce ROS levels have been shown to ameliorate arsenic-induced lesions. However, emerging evidence suggests that constructive activation of antioxidative pathways and decreased ROS levels contribute to chronic arsenic toxicity in some cases. This review details the pathways involved in arsenic-induced redox imbalance, as well as current studies on prophylaxis and treatment strategies using antioxidants.
166 citations
TL;DR: This review provided the latest research information on the differences in toxicity between MPs and NPs in the digestive system, reproductive system and nervous system, and explored the possible reasons for differences for the first time.
131 citations
TL;DR: It is shown that CPF could trigger oxidative stress and induce apoptosis and necroptosis in fish liver cells by regulating the ROS/PTEN/PI3K/AKT axis, and the type of damage induced was dose-dependent.
103 citations