Author
Donn M. Ebert
Bio: Donn M. Ebert is an academic researcher. The author has contributed to research in topics: Captopril & Angiotensin II. The author has an hindex of 1, co-authored 1 publications receiving 59 citations.
Topics: Captopril, Angiotensin II
Papers
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TL;DR: The blockade of the captopril effects by naloxone suggests that brain opioid peptides play a role in this behavioral effect ofcaptopril, and the conclusion is guarded, as the positive effects may be related to motor stimulation.
60 citations
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TL;DR: The hypothesis that exposure to chronic mild stress (CMS), an experimental model of depression that induces anhedonia in rats, is sufficient to activate the production of proinflammatory cytokines and stress hormones that are detrimental to the heart and vascular system is examined.
214 citations
TL;DR: Current research efforts directed at the use of angiotensin analogues in the treatment of clinical disorders such as memory dysfunction, cerebral blood flow and cerebroprotection, stress, depression, alcohol consumption, seizure, Alzheimer's and Parkinson's diseases, and diabetes are summarized.
205 citations
TL;DR: Evidence concerning the role of the renin-angiotensin system in learning and memory is contradictory, although more studies support the proposal that ang Elliotensin reduces cognitive function.
191 citations
TL;DR: The renin-angiotensin system mediates several classic physiologies including body water and electrolyte homeostasis, blood pressure, cyclicity of reproductive hormones and sexual behaviors, and the regulation of pituitary gland hormones.
132 citations
TL;DR: These findings suggest that angiotensin receptor ligands may have potential in the prevention or even reversal of vascular dementias and AD and the use of such agents in the treatment of hypertension coexisting with depression or anxiety.
Abstract: The brain renin–angiotensin system (RAS), which is comprised of a variety of peptides including angiotensin II, angiotensin III and angiotensin IV acting on AT1, AT2 and AT4 receptors, is important in cognition and anxiety. Perturbation of the RAS improves basal cognition and reverses age-, scopolamine-, ethanol- and diabetes-induced deficits. In studies of dementias and Alzheimer’s disease (AD), some studies have shown that antihypertensive drugs, including angiotensin-converting enzyme inhibitors, have some moderate effects on cognitive decline, but that the angiotensin receptor antagonist losartan has a significantly beneficial effect. These findings suggest that angiotensin receptor ligands may have potential in the prevention or even reversal of vascular dementias and AD. With respect to depression and anxiety, there is similar experimental evidence from animal models that drugs acting on the RAS may be antidepressant or anxiolytic, but insufficient clinical data exist. Such effects, if proven, could...
99 citations