Donna C. Ferguson

TL;DR: MSK-ACCESS as mentioned in this paper is an NGS assay for detection of very low frequency somatic alterations in 129 genes and achieved 92% sensitivity in de-novo mutation calling down to 0.5% allele frequency and 99% for a priori mutation profiling.

TL;DR: In this paper, the prevalence of ERBB family KDDs across multiple human cancers and evaluate the functional biochemistry of EGFR-KDD as it relates to pathogenesis and potential therapeutic intervention.

TL;DR: F3T3-positive GBMs exhibit distinct biological features, underscoring the importance of pursuing molecular studies prior to clinical trial enrollment and targeted treatment, and their impact on survival in 906 IDH-wildtype GBM patients.

TL;DR: The experience illustrates the importance of analyzing a matched normal sample when interpreting cfDNA results and highlights the potential of cfDNA profiling to guide treatment selection, monitor treatment response, and identify mechanisms of treatment resistance.

TL;DR: In this paper, the authors assessed the prevalence and clinicopathologic features associated with AR-V7 in a large BC cohort and concluded that positive AR IHC and apocrine morphology are pathologic features that may indicate testing for ARV7 is warranted in both primary and metastatic BC in the appropriate clinical context.