D
Doris Chen
Researcher at Austrian Academy of Sciences
Publications - 30
Citations - 6427
Doris Chen is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Germline mutation & Myelofibrosis. The author has an hindex of 17, co-authored 28 publications receiving 5804 citations. Previous affiliations of Doris Chen include University of Vienna & Research Institute of Molecular Pathology.
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Journal ArticleDOI
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Georg Dietzl,Doris Chen,Frank Schnorrer,Kuan-Chung Su,Yulia Barinova,Michaela Fellner,Michaela Fellner,Beate Gasser,Kaolin Kinsey,Kaolin Kinsey,Silvia Oppel,Silvia Oppel,Susanne Scheiblauer,Africa Couto,Vincent Marra,Krystyna Keleman,Krystyna Keleman,Barry J. Dickson,Barry J. Dickson +18 more
TL;DR: The generation and validation of a genome-wide library of Drosophila melanogaster RNAi transgenes, enabling the conditional inactivation of gene function in specific tissues of the intact organism and opening up the prospect of systematically analysing gene functions in any tissue and at any stage of the Drosophile lifespan.
Journal ArticleDOI
Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms
Thorsten Klampfl,Heinz Gisslinger,Ashot S. Harutyunyan,Harini Nivarthi,Elisa Rumi,Jelena D. Milosevic,Nicole C.C. Them,Tiina Berg,Bettina Gisslinger,Daniela Pietra,Doris Chen,Gregory I. Vladimer,Klaudia Bagienski,Chiara Milanesi,Ilaria Carola Casetti,Emanuela Sant'Antonio,Virginia Valeria Ferretti,Chiara Elena,Fiorella Schischlik,Ciara Cleary,Melanie Six,Martin Schalling,Andreas Schönegger,Christoph Bock,Luca Malcovati,Cristiana Pascutto,Giulio Superti-Furga,Mario Cazzola,Robert Kralovics +28 more
TL;DR: Most patients with essential thrombocythemia or primary myelofibrosis that was not associated with a JAK2 or MPL alteration carried a somatic mutation in CALR, and patients with mutated CALR had a lower risk ofThrombosis and longer overall survival than patients with mutations in J AK2.
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Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi
Jennifer L. Mummery-Widmer,Masakazu Yamazaki,Masakazu Yamazaki,Thomas Stoeger,Maria Novatchkova,Maria Novatchkova,Sheetal Bhalerao,Sheetal Bhalerao,Doris Chen,Georg Dietzl,Barry J. Dickson,Juergen A. Knoblich +11 more
TL;DR: The use of a library of Drosophila strains expressing inducible hairpin RNAi constructs to study the Notch signalling pathway during external sensory organ development is reported, showing that complex developmental processes can be analysed on a genome-wide level and provide a unique resource for functional annotation of the Drosophile genome.
Journal ArticleDOI
RNA chaperones, RNA annealers and RNA helicases.
Lukas Rajkowitsch,Doris Chen,Sabine Stampfl,Katharina Semrad,Christina Waldsich,Oliver Mayer,Michael F. Jantsch,Robert Konrat,Udo Bläsi,Renée Schroeder +9 more
TL;DR: The different mechanisms RNA chaperones might use to promote folding including the recently proposed theory of protein disorder as a key element in triggering RNA-protein interactions are addressed.
Journal ArticleDOI
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line
Patrick Essletzbichler,Tomasz Konopka,Federica Santoro,Doris Chen,Bianca V. Gapp,Robert Kralovics,Thijn R. Brummelkamp,Thijn R. Brummelkamp,Sebastian M.B. Nijman,Tilmann Bürckstümmer +9 more
TL;DR: In this paper, the authors employed a CRISPR/Cas9-based genome engineering strategy to excise this sizeable chromosomal fragment and to efficiently and reproducibly derive clones that retain their haploid state.