D
Doris Marko
Researcher at University of Vienna
Publications - 218
Citations - 8708
Doris Marko is an academic researcher from University of Vienna. The author has contributed to research in topics: Alternariol & Topoisomerase. The author has an hindex of 42, co-authored 198 publications receiving 7192 citations. Previous affiliations of Doris Marko include Centre national de la recherche scientifique & Schrödinger.
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Journal ArticleDOI
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
Ralph Hoessel,Sophie Leclerc,Jane A. Endicott,Martin E. M. Nobel,Alison M. Lawrie,Paul Tunnah,Maryse Leost,Eve Damiens,Dominique Marie,Doris Marko,Ellen Niederberger,Weici Tang,Gerhard Eisenbrand,Laurent Meijer +13 more
TL;DR: Indirubin-3′-monoxime inhibits the proliferation of a large range of cells, mainly through arresting the cells in the G2/M phase of the cell cycle, which has implications for therapeutic optimization of indigoids.
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Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease A PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE INHIBITORS?
Sophie Leclerc,Matthieu Garnier,Ralph Hoessel,Doris Marko,James A. Bibb,Gretchen L. Snyder,Paul Greengard,Jacek Biernat,Yong-Zhong Wu,Eva-Maria Mandelkow,Gerhard Eisenbrand,Laurent Meijer +11 more
TL;DR: It is reported here that indirubins are also powerful inhibitors (IC(50): 5-50 nm) of an evolutionarily related kinase, glycogen synthase kinase-3beta (GSK-3 beta), and it is shown that many, but not all, reported CDK inhibitors are powerful inhibitors of GSK-3 Beta.
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Proposal of a comprehensive definition of modified and other forms of mycotoxins including “masked” mycotoxins
Michael Rychlik,Hans-Ulrich Humpf,Doris Marko,Sven Dänicke,Angela Mally,Franz Berthiller,H. Klaffke,Nicole Lorenz +7 more
TL;DR: To harmonize future scientific wording and subsequent legislation, it is suggested that the term “modified mycotoxins” should be used in the future and the term’s kept for the fraction of biologically modified myotoxins that were conjugated by plants.
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The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor.
TL;DR: The anthocyanidins cy and del are potent inhibitors of the EGFR, shutting off downstream signaling cascades, which might contribute substantially to the growth-inhibitory properties of these natural food constituents.
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Risk assessment of aflatoxins in food
Dieter Schrenk,Margherita Bignami,Laurent Bodin,James K. Chipman,Jesús del Mazo,Bettina Grasl-Kraupp,Christer Hogstrand,Laurentius Hoogenboom,Jean-Charles Leblanc,Carlo Nebbia,Elsa Nielsen,Evangelia E. Ntzani,Annette Petersen,Salomon Sand,Tanja Schwerdtle,Christiane Vleminckx,Doris Marko,Isabelle P. Oswald,Aldert H. Piersma,Michael Routledge,Josef Rudolf Schlatter,Katleen Baert,Petra Gergelova,Heather M. Wallace +23 more
TL;DR: The estimated cancer risks in humans following exposure to AFB1 and AFM1 are in‐line with the conclusion drawn from the MOEs, and the conclusions also apply to the combined exposure to all five aflatoxins.