D
Douglas A. Horton
Researcher at University of Queensland
Publications - 9
Citations - 2937
Douglas A. Horton is an academic researcher from University of Queensland. The author has contributed to research in topics: Cyclic peptide & Solid-phase synthesis. The author has an hindex of 5, co-authored 9 publications receiving 2737 citations.
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Journal ArticleDOI
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
Journal ArticleDOI
Exploring privileged structures: the combinatorial synthesis of cyclic peptides.
TL;DR: This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries, thereby justifying their inclusion as privileged structures.
Journal ArticleDOI
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
Journal ArticleDOI
Exploring privileged structures: The combinatorial synthesis of cyclic peptides
TL;DR: This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries, thereby justifying their inclusion as privileged structures.
Journal ArticleDOI
Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification
Douglas A. Horton,Gregory T. Bourne,Justin F. Coughlan,Sonya M. Kaiser,Carolyn Jacobs,Alun Jones,Andreas Rühmann,Jill Y. Turner,Mark L. Smythe +8 more
TL;DR: A suite of techniques were developed to enable characterisation of cyclic tetrapeptide isomers, including the Edman degradation and mass spectrometry/mass spectromaetry, to illustrate the success of the ring contraction strategy and a library ofcyclic tetrapptides was synthesised.