D
Douglas B. Kell
Researcher at University of Liverpool
Publications - 657
Citations - 55792
Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.
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Journal ArticleDOI
Transmembrane respiration-driven H+ translocation is unimpaired in an eup mutant of Escherichia coli.
TL;DR: It appears that the role of the eup gene product lies in the utilization of energized protons pumped across the E. coli cytoplasmic membrane.
Journal ArticleDOI
SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.
Pablo Carbonell,Andrew Currin,Mark S. Dunstan,Donal Fellows,Adrian J. Jervis,Nicholas J. W. Rattray,Christopher J. Robinson,Neil Swainston,Maria Vinaixa,Alan Williams,Cunyu Yan,Perdita E. Barran,Rainer Breitling,George Guo-Qiang Chen,Jean-Loup Faulon,Carole Goble,Royston Goodacre,Douglas B. Kell,Rosalind Le Feuvre,Jason Micklefield,Nigel S. Scrutton,Philip Shapira,Eriko Takano,Nicholas J. Turner +23 more
TL;DR: The Manchester Synthetic Biology Research Centre's integrated technology platforms provide a unique capability to facilitate predictable engineering of microbial bio-factories for chemicals production.
Posted ContentDOI
DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach
Yash Khemchandani,Stephen O’Hagan,Soumitra Samanta,Neil Swainston,Timothy J. Roberts,Danushka Bollegala,Douglas B. Kell +6 more
TL;DR: The method is extended to use a multi-objective reward function, in this case for generating novel molecules that bind with dopamine transporters but not with those for norepinephrine, and should be generally applicable to the generation in silico of molecules with desirable properties.
Journal ArticleDOI
Intelligent host engineering for metabolic flux optimisation in biotechnology.
TL;DR: In this paper, the authors discuss the relevant issues for those wishing to understand and exploit those modern genome-wide host engineering tools and thinking that have been designed and developed to optimise fluxes towards desirable products in biotechnological processes, with a focus on microbial systems.
Journal ArticleDOI
Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products.
Steve O'Hagan,Douglas B. Kell +1 more
TL;DR: F fluorophores do indeed offer a much wider opportunity than had possibly been realised to be used as surrogate uptake molecules in the competitive or trans-stimulation assay of membrane transporter activities, and does overlap with a significant part of both the drug space and natural products space.