Douglas B. Kell

TL;DR: The application of wavelet denoising to infrared spectra was investigated in this article, where six different wavelet methods (SURE, VISU, HYBRID, MINMAX, MAD, and WAVELET PACKETS) were applied to pure infrared spectrum with various levels of homo- and heteroscedastic noise.

TL;DR: An automated pipeline for the discovery and optimization of biosynthetic pathways for microbial production of fine chemicals is presented and application of the pipeline to optimize an alkaloids pathway demonstrates how it could facilitate the rapid optimization of microbial strains for production of any chemical compound of interest.

TL;DR: The newly emerging field of systems biology involves a judicious interplay between high‐throughput ‘wet’ experimentation, computational modelling and technology development, coupled to the world of ideas and theory, such that systems biology is not at all confined to hypothesis‐dependent studies, with intelligent, principled, hypothesis‐generating studies of high importance and consequently very far from aimless fishing expeditions.

TL;DR: It is concluded that the presence of a small fraction of viable cells at the onset of resuscitation facilitates the recovery of the majority of the remaining (dormant) cells.

TL;DR: Using quantitative transcriptomics data acquired from Saccharomyces cerevisiae cultures under two growth conditions, the method outperforms traditional approaches for predicting experimentally measured exometabolic flux that are reliant upon maximisation of the rate of biomass production.