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Douglas B. Kell
Researcher at University of Liverpool
Publications - 657
Citations - 55792
Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.
Papers
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Journal ArticleDOI
Analysis of the Metabolic Footprint and Tissue Metabolome of Placental Villous Explants Cultured at Different Oxygen Tensions Reveals Novel Redox Biomarkers
Alexander E. P. Heazell,Martin Brown,Warwick B. Dunn,Stephanie Worton,Ian P. Crocker,Philip N. Baker,Douglas B. Kell +6 more
TL;DR: It is concluded that metabolomic strategies offer a novel approach to investigate placental function when conducted under carefully controlled conditions, with appropriate statistical analysis, metabolic differences can be identified in placental explants in response to altered O2 tension.
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Metabolomic biomarkers: search, discovery and validation
TL;DR: There are many reasons why it is appropriate to concentrate on the metabolome (BOX 1), the most significant being that it hinges upon the properties of networks, and is thus an issue of systems biology.
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Metabolomics, machine learning and modelling: towards an understanding of the language of cells.
TL;DR: It is determined that many biological signals may be frequency-rather than amplitude-encoded, and closed loop machine learning and its use in the optimization of scientific instrumentation, and the ability to effect high-quality and quasi-continuous optical images of cells are determined.
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L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model.
Rachel D. Williamson,Fergus P. McCarthy,Samprikta Manna,Emer Groarke,Douglas B. Kell,Douglas B. Kell,Louise C. Kenny,Cathal McCarthy +7 more
TL;DR: Data support the potential use of ERG for the treatment of preeclampsia and show that L-(+)-ergothioneine (ERG)—an unusual amino acid betaine derived from histidine—has important cytoprotective and antioxidant properties under conditions of high oxidative stress.
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The control and measurement of ‘CO2’ during fermentations
Neil M. Dixon,Douglas B. Kell +1 more
TL;DR: In this paper, the authors discuss the trade-off between resolution, precision, accuracy, response time, ease of use and expense of mass spectrometers for potentiometric devices.