Douglas B. Kell

TL;DR: Making use of the NK fitness landscape model, the effects of mutation rate, crossover and selection pressure on the performance of directed evolution are analysed and it is found that purely evolutionary techniques fare better than do model-based approaches across all but the smoothest landscapes.

TL;DR: Software comes in various forms, from the hair shirt style of the command line to fully blown, GUI-based commercial offerings, in which loosely coupled, individual processing nodes can be ?

TL;DR: High-throughput flow cytometry is used to assess the ability of individual gene knockout strains of E coli to take up two membrane-permeable, cationic fluorescent dyes, namely the carbocyanine diS-C3(5) and the DNA dye SYBR Green, concluding that the uptake of these dyes may be catalysed by a great many transporters of putatively broad and presently unknown specificity.

TL;DR: This conclusion is greatly strengthened by the demonstration herein that the generation of harmonics by a strain containing a vandate-resistant H(+)-ATPase is also highly resistant to sodium metavanadate.

TL;DR: Observations lead to the view that the energy-coupling proton-transfer processes utilised in reactions such as electron-transport phosphorylation are confined to the membrane phase.