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Douglas B. Kell

Researcher at University of Liverpool

Publications -  657
Citations -  55792

Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.

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Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease.

TL;DR: It is hypothesised, and here show, that this unusual clotting in the blood of patients with Parkinson’s Disease can be prevented by LBP, and this adds further evidence implicating inflammatory microbial cell wall products as an accompaniment to the disease, and may be part of its aetiology.
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A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation

TL;DR: A systematic survey using computational bifurcation theory to explore the relationship between the intensity of TNFα stimulation and the existence of sustained NF-κB oscillations and defines scores to quantify the sensitivity of the dynamics of the system to variation in its parameters and establish that the qualitative dynamics are most sensitive to the details of NF-σB mediated gene transcription.
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Stimulation by potassium ions of the growth of Rhizopus oligosporus during liquid-and solid-substrate fermentations

TL;DR: The present report represents one of the few demonstrations of a mineral deficiency during the growth of a fungus on a natural, solid substrate.
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Prevalence of readily detected amyloid blood clots in 'unclotted' Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report.

TL;DR: It is shown here that microclots can be detected in the native plasma of twenty COVID-19, as well as ten T2DM patients, without the addition of any clotting agent, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain.
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The physiology of Clostridium sporogenes NCIB 8053 growing in defined media

TL;DR: The physiology of Clostridium sporogenes was investigated in defined, minimal media and it was judged that glucose was metabolized via the Embden-Meyerhof-Parnas pathway and the addition of L-proline to the medium caused a significant increase in the molar growth yield.