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Douglas B. Kell
Researcher at University of Liverpool
Publications - 657
Citations - 55792
Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.
Papers
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Journal ArticleDOI
Improving the interpretation of multivariate and rule induction models by using a peak parameter representation
TL;DR: This paper demonstrates that the interpretation of multivariate calibration and rule induction classification models can be significantly improved by adopting a new representation of data profiles containing identifiable peaks based on Gaussian or Lorentzian curve parameters by non-linear curve fitting.
Journal ArticleDOI
Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.
TL;DR: It is indeed possible to find molecules that manipulate the expression of transporters that are involved in the bioactivity of a pharmaceutical drug, and this opens up an entirely new area, that of chemical genomics-based drug targeting.
Book ChapterDOI
Localized protonic coupling: overview and critical evaluation of techniques.
TL;DR: An overview and critical evaluation of the techniques of localized protonic coupling and the harmonization of double inhibitor-titration protocols within the framework of metabolic control theory might constitute a particularly rigorous and rewarding approach to this problem.
The cellular uptake of pharmaceutical drugs is mainly carrier-mediated and is thus an issue not so much of biophysics but of systems biology
Douglas B. Kell,Paul D. Dobson +1 more
TL;DR: Carrier-mediated and active uptake of drugs is far more common than is usually assumed and has considerable implications for the design of libraries for drug discovery and development, as well as for chemical genetics/genomics and systems chemistry.
Journal ArticleDOI
An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.
Vojtech Dvorak,Tabea Wiedmer,Alvaro Ingles-Prieto,Patrick Altermatt,Helena Batoulis,Felix Bärenz,Eckhard Bender,Daniela Digles,Franz Dürrenberger,Laura H. Heitman,Adriaan P. IJzerman,Douglas B. Kell,Douglas B. Kell,Stefanie Kickinger,Daniel Körzö,Philipp Leippe,Thomas Licher,Vania Manolova,Riccardo Rizzetto,Francesca Sassone,Lia Scarabottolo,Avner Schlessinger,Vanessa Schneider,Hubert J. Sijben,Anna Lena Steck,Hanna Sundström,Sara Tremolada,Maria Wilhelm,Marina Wright Muelas,Diana Zindel,Claire M. Steppan,Giulio Superti-Furga,Giulio Superti-Furga +32 more
TL;DR: A comprehensive overview of state-of-the-art cellular assay technologies for solute carrier (SLC) research can be found in this article, where the authors discuss relevant SLC characteristics enabling the choice of an optimal assay technology.