D
Douglas B. Kell
Researcher at University of Liverpool
Publications - 657
Citations - 55792
Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.
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Journal Article
Molecular phenotyping of a UK population: defining the human serum metabolome. Metabolomics
Warwick B. Dunn,Wanchang Lin,David Broadhurst,Paul Begley,Martin Brown,Eva Zelena,Andrew A. Vaughan,Antony Halsall,Harding N,Joshua Knowles,Sue Francis-McIntyre,Andy Tseng,David I. Ellis,Stephen O’Hagan,Aarons G,Boben Benjamin,Stephen Chew-Graham,Carly Moseley,Paula Potter,Catherine L. Winder,Potts C,Paula Thornton,McWhirter C,Mohammed Zubair,Martin Pan,Alistair Burns,Cruickshank Jk,Gordon C Jayson,Nitin Purandare,Frederick C. W. Wu,J. D. Finn,John N. Haselden,Andrew W. Nicholls,Ian D. Wilson,Royston Goodacre,Douglas B. Kell +35 more
TL;DR: Overall, this is a large scale and non-targeted chromatographic MS-based metabolomics study, using samples from over 1,000 individuals, to provide a comprehensive measurement of their serum metabolomes, providing an important baseline or reference dataset for understanding the ‘normal’ relative concentrations and variation in the human serum metabolome.
Journal ArticleDOI
An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines.
Marina Wright Muelas,Ivayla Roberts,Farah Mughal,Steve O'Hagan,Philip J. Day,Philip J. Day,Douglas B. Kell +6 more
TL;DR: A new, 15-min untargeted metabolome method allows for the robust and convenient measurement of differences in the uptake of serum compounds by cell lines following incubation in serum, thereby advancing the knowledge of transporter substrates, both natural and xenobiotic compounds.
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Growth energetics of Clostridium sporogenes NCIB 8053: modulation by CO2
TL;DR: A futile cycle involving carbon dioxide is proposed as a factor contributing to the variable extent of free energy dissipation within this organism.
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GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries
Andrew Currin,Jane Kwok,Joanna C. Sadler,Elizabeth L. Bell,Neil Swainston,Maria Ababi,Philip J. R. Day,Nicholas J. Turner,Douglas B. Kell +8 more
TL;DR: GeneORator is introduced, a novel strategy for creating DNA libraries based on the Boolean logical OR operator, which enables the screening of a greater diversity of mutation combinations, accessing a larger area of a protein’s sequence space.
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Convergent evolution to an aptamer observed in small populations on DNA microarrays
TL;DR: The development of aptamers on custom synthesized DNA microarrays is used to observe the paths taken through sequence-fitness space by three different evolutionary regimes: asexual reproduction, recombination and model-based evolution.