D
Douglas Grunwald
Researcher at University of Minnesota
Publications - 4
Citations - 403
Douglas Grunwald is an academic researcher from University of Minnesota. The author has contributed to research in topics: Autophagy & Autophagy-related protein 13. The author has an hindex of 4, co-authored 4 publications receiving 271 citations.
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Journal ArticleDOI
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
Ji Man Park,Chang Hwa Jung,Minchul Seo,Neil Michael Otto,Douglas Grunwald,Kwan Hyun Kim,Branden S. Moriarity,Young Mi Kim,Colby G. Starker,Richard Seonghun Nho,Daniel F. Voytas,Do Hyung Kim +11 more
TL;DR: A key molecular event is defined for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1, and hierarchical relations between the ULK 1 activation and other autophagy proteins involved in phagophore formation are demonstrated.
Journal ArticleDOI
ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.
Ji Man Park,Minchul Seo,Chang Hwa Jung,Douglas Grunwald,Matthew D. Stone,Neil Michael Otto,Erik A. Toso,Yeseul Ahn,Michael Kyba,Timothy J. Griffin,LeeAnn Higgins,Do Hyung Kim +11 more
TL;DR: It is demonstrated that BECN1 Ser30 is a ULK1 target site whose phosphorylation activates the ATG14-containing PIK3C3 complex and stimulates autophagosome formation in response to amino acid starvation, hypoxia, and MTORC1 inhibition.
Journal ArticleDOI
GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy induction
TL;DR: This study demonstrates differential binding and opposite regulation of the ULK1 complex by GABARAPs and LC3s, and an important role of theULK1- and ATG13-ATG8 interactions in autophagy induction.
Journal ArticleDOI
An expanded role for mTORC1 in autophagy.
TL;DR: The roles of mTORC1 in autophagy were expanded by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of m TORC1, and this finding has provided new insight into the roles in cellular membrane processes and cancer.