D
Douglas R. Higgs
Researcher at University of Oxford
Publications - 327
Citations - 25784
Douglas R. Higgs is an academic researcher from University of Oxford. The author has contributed to research in topics: Gene & Globin. The author has an hindex of 83, co-authored 319 publications receiving 23665 citations. Previous affiliations of Douglas R. Higgs include University of London & University of the West Indies.
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Journal ArticleDOI
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D Goldberg,Laura A. Banaszynski,Kyung-Min Noh,Peter W. Lewis,Simon J. Elsaesser,Sonja C. Stadler,Scott Dewell,Martin J. Law,Xingyi Guo,Xuan Li,Duancheng Wen,Duancheng Wen,Ariane Chapgier,Russell Dekelver,Jeffrey C. Miller,Ya Li Lee,Elizabeth A. Boydston,Michael C. Holmes,Philip D. Gregory,John M. Greally,Shahin Rafii,Shahin Rafii,Chingwen Yang,Peter J. Scambler,David Garrick,Richard J. Gibbons,Douglas R. Higgs,Ileana M. Cristea,Fyodor D. Urnov,Deyou Zheng,C. David Allis +30 more
TL;DR: It is demonstrated that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells.
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The polycystic kidney-disease-1 gene encodes a 14-kb transcript and lies within a duplicated region on chromosome-16
Christopher S. Ward,Belén Peral,Jim R. Hughes,Siep Thomas,Vicki Gamble,A MacCarthy,Jackie Sloane-Stanley,Peter Buckle,Peter Kearney,Douglas R. Higgs,C. Ratcliffe,Peter C. Harris,Jeroen H. Roelfsema,Lia Spruit,Jasper J. Saris,Hans G. Dauwerse,Dorien J.M. Peters,Martijn H. Breuning,Mark Nellist,Phillip T. Brook-Carter,Magitha M. Maheshwar,Isabel Cordeiro,Heloisa Santos,Pedro Cabral,Julian R. Sampson,Bart Janssen,Arjenne L. W. Hesseling-Janssen,Ans M.W. van den Ouweland,Bert Eussen,S. Verhoef,Dick Lindhout,Dicky J. J. Halley +31 more
TL;DR: Partial sequence analysis of the PKD1 transcript shows that it encodes a novel protein whose function is at present unknown, and a chromosome translocation associated with ADPKD that disrupts a gene (PBP) encoding a 14 kb transcript in thePKD1 candidate region is identified.
Journal ArticleDOI
A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16
Stephen T. Reeders,Martijn H. Breuning,Kay E. Davies,Robert D. Nicholls,Andrew P. Jarman,Douglas R. Higgs,Peter L. Pearson,D. J. Weatherall +7 more
TL;DR: It is shown that the APCKD locus is closely linked to the α-globin locus on the short arm of chromosome 16 (\[zcirc] = 25.85, \[thetacirc]=0.05) and this condition cannot be identified prenatally.
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Mutations in a Putative Global Transcriptional Regulator Cause X-linked Mental Retardation With Alpha-Thalassemia (ATR-X Syndrome)
TL;DR: The complex ATR-X phenotype suggests that XH2, when mutated, down-regulates expression of several genes, including the alpha-globin genes, indicating that it could be a global transcriptional regulator.
Journal ArticleDOI
Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease.
Cristina Tufarelli,Jackie S. Stanley,David Garrick,Jackie A Sharpe,Helena Ayyub,William G. Wood,Douglas R. Higgs +6 more
TL;DR: It is shown that in the affected individual, in a transgenic model and in differentiating embryonic stem cells, transcription of antisense RNA mediates silencing and methylation of the associated CpG island.