D
Douglas T. Carrell
Researcher at University of Utah
Publications - 319
Citations - 16094
Douglas T. Carrell is an academic researcher from University of Utah. The author has contributed to research in topics: Sperm & Male infertility. The author has an hindex of 63, co-authored 313 publications receiving 13657 citations. Previous affiliations of Douglas T. Carrell include University of Hawaii & Abbott Northwestern Hospital.
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Journal ArticleDOI
Distinctive chromatin in human sperm packages genes for embryo development
Saher Sue Hammoud,David A. Nix,Haiying Zhang,Jahnvi Purwar,Douglas T. Carrell,Bradley R. Cairns +5 more
TL;DR: It is shown that the retained nucleosomes are significantly enriched at loci of developmental importance, including imprinted gene clusters, microRNA clusters, HOX genes clusters, and the promoters of stand-alone developmental transcription and signalling factors.
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Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Peter G. Hendrickson,Jessie Dorais,Jessie Dorais,Edward J. Grow,Jennifer L. Whiddon,Jong-Won Lim,Candice L. Wike,Bradley D. Weaver,Christian Pflueger,Benjamin R. Emery,Aaron L. Wilcox,David A. Nix,C. Matthew Peterson,Stephen J. Tapscott,Douglas T. Carrell,Bradley R. Cairns +15 more
TL;DR: Mouse DUX and human DUX4 are proposed as major drivers of the cleavage or 2C state, which is strongly resembling that of mouse 2C embryos.
Journal ArticleDOI
Male obesity and alteration in sperm parameters.
Ahmad O. Hammoud,Nicole Wilde,Mark Gibson,Anna L. Parks,Douglas T. Carrell,A. Wayne Meikle,A. Wayne Meikle +6 more
TL;DR: Male obesity is associated with increased incidence of low sperm concentration and low progressively motile sperm count.
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The adult human testis transcriptional cell atlas
Jingtao Guo,Edward J. Grow,Hana Mlcochova,Geoffrey J. Maher,Cecilia Lindskog,Xichen Nie,Yixuan Guo,Yodai Takei,Jina Yun,Long Cai,Robin D. Kim,Douglas T. Carrell,Anne Goriely,James M. Hotaling,Bradley R. Cairns +14 more
TL;DR: The datasets describe key transcriptional and epigenetic signatures of the normal adult human testis, and provide new insights into germ cell developmental transitions and plasticity.
Journal ArticleDOI
Altered protamine expression and diminished spermatogenesis: what is the link?
TL;DR: Two hypotheses are suggested: (i) that abnormal protamine expression is indicative of a generalized defect in mRNA storage and/or translation which affects other mRNA transcripts or (ii) that protamines may act as a checkpoint of spermatogenesis.