D
Dov Soffer
Researcher at Hebrew University of Jerusalem
Publications - 65
Citations - 7136
Dov Soffer is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Encephalomyelitis & Myopathy. The author has an hindex of 30, co-authored 65 publications receiving 6909 citations.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
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Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties.
TL;DR: A model of closed head injury in rats was developed using a calibrated weight-drop device and the development of edema was studied in various brain regions using a linear specific gravity gradient column.
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Mutations in the Fatty Acid 2-Hydroxylase Gene Are Associated with Leukodystrophy with Spastic Paraparesis and Dystonia
Simon Edvardson,Hiroko Hama,Avraham Shaag,John M. Gomori,Itai Berger,Dov Soffer,Stanley H. Korman,Ilana Taustein,Ann Saada,Orly Elpeleg +9 more
TL;DR: To the knowledge, this is the first identified deficiency of a lipid component of myelin and the clinical phenotype underscores the importance of the 2-hydroxylation of galactolipids for myelin maturation.
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Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus.
Eli Pikarsky,Ariel Ronen,Julia Abramowitz,Berta Levavi-Sivan,Marina Hutoran,Yechiam Shapira,Michael Steinitz,Ayana Perelberg,Ayana Perelberg,Dov Soffer,Moshe Kotler +10 more
TL;DR: The virus causing the disease from sick fish, propagated it in koi fin cell culture, and shown that virus from a single clone causes lethal disease in carp and koi upon infection are called carp interstitial nephritis and gill necrosis virus.
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Adult polyglucosan body disease in Ashkenazi Jewish patients carrying the Tyr329Ser mutation in the glycogen-branching enzyme gene.
Alexander Lossos,Zeev Meiner,Varda Barash,Dov Soffer,Ilana Schlesinger,Oded Abramsky,Zohar Argov,Shoshi Shpitzen,Vardiella Meiner +8 more
TL;DR: The clinical and biochemical APBD phenotype in all five families cosegregated with the Tyr329Ser mutation, not detected in 140 controls, which explains the late onset and slowly progressive course of APBD in patients.