Duncan B. Clark

TL;DR: The overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development, and brain volume robustly and positively correlated with age of onset of PTSD trauma and negatively correlated with duration of abuse.

TL;DR: Cross-sectional and longitudinal analyses indicated that neurobehavioral disinhibition is a component of the liability to early age at onset of substance use disorder.

TL;DR: Findings suggest that, during adolescence, the hippocampus may be particularly susceptible to the adverse effects of alcohol.

TL;DR: The baseline neuroimaging processing and subject-level analysis methods used by the Adolescent Brain Cognitive Development Study are described to be a resource of unprecedented scale and depth for studying typical and atypical development.

TL;DR: Findings suggest that a smaller prefrontal cortex is associated with early-onset drinking in individuals with comorbid mental disorders.