D
Dunyaporn Trachootham
Researcher at Mahidol University
Publications - 44
Citations - 8198
Dunyaporn Trachootham is an academic researcher from Mahidol University. The author has contributed to research in topics: Cancer cell & Medicine. The author has an hindex of 13, co-authored 34 publications receiving 7064 citations. Previous affiliations of Dunyaporn Trachootham include Thammasat University & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
Redox Regulation of Cell Survival
Dunyaporn Trachootham,Dunyaporn Trachootham,Dunyaporn Trachootham,Weiqin Lu,Marcia A. Ogasawara,Nilsa Rivera-Del Valle,Nilsa Rivera-Del Valle,Peng Huang +7 more
TL;DR: The current understanding of how disturbance in redox homeostasis may affect cell death and contribute to the development of diseases such as cancer and degenerative disorders is reviewed and the basic knowledge on redox regulation of cell survival can be used to develop strategies for the treatment or prevention of those diseases.
Journal ArticleDOI
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
Dunyaporn Trachootham,Yan Zhou,Hui Zhang,Hui Zhang,Y. Demizu,Zhao Chen,Zhao Chen,Helene Pelicano,Paul J. Chiao,Paul J. Chiao,Geetha Achanta,Ralph B. Arlinghaus,Ralph B. Arlinghaus,Jinsong Liu,Jinsong Liu,Peng Huang,Peng Huang +16 more
TL;DR: It is shown that abnormal increases in ROS can be exploited to selectively kill cancer cells using beta-phenylethyl isothiocyanate (PEITC), which exhibits therapeutic activity and prolongs animal survival in vivo.
Journal ArticleDOI
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia.
Wan Zhang,Dunyaporn Trachootham,Dunyaporn Trachootham,Jinyun Liu,Gang Chen,Helene Pelicano,Celia Garcia-Prieto,Weiqin Lu,Jan A. Burger,Carlo M. Croce,William Plunkett,Michael J. Keating,Peng Huang +12 more
TL;DR: A biochemical mechanism by which bone marrow stromal cells modulate the redox status of chronic lymphocytic leukaemia (CLL) cells and promote cellular survival and drug resistance is shown.
Journal ArticleDOI
K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis.
Yumin Hu,Weiqin Lu,Gang Chen,Peng Wang,Zhao Chen,Yan Zhou,Marcia A. Ogasawara,Dunyaporn Trachootham,Dunyaporn Trachootham,Li Feng,Helene Pelicano,Paul J. Chiao,Michael J. Keating,Guillermo Garcia-Manero,Peng Huang +14 more
TL;DR: This study suggests that induction of mitochondrial dysfunction is an important mechanism by which K-rasG12V causes metabolic changes and ROS stress in cancer cells, and promotes tumor development.