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E.F. Gavrilov

Bio: E.F. Gavrilov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Cytotoxicity & Reactivity (chemistry). The author has an hindex of 1, co-authored 1 publications receiving 6 citations.

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Journal ArticleDOI
TL;DR: The diffusion coefficient of ammonium perchlorate and copper hypophosphite at 20°C was found to be 10−10 cm2/sec and 10−9 cm 2/sec, respectively as mentioned in this paper.

6 citations

Journal ArticleDOI
TL;DR: In this article , the synthesis of four gold compounds containing chloro and biologically active protonated thiosemicarbazones based on 5-nitrofuryl (L=HSTC) was described.
Abstract: This work describes the synthesis of four gold(I) [AuClL] compounds containing chloro and biologically active protonated thiosemicarbazones based on 5-nitrofuryl (L=HSTC). The stability of the compounds in dichloromethane, DMSO, and DMSO/culture media solutions was investigated by spectroscopy, cyclic voltammetry, and conductimetry, indicating the formation overtime of cationic monometallic [Au(HTSC)(DMSO)]± or [Au(HTSC)2 ]± , and/or dimeric species. Neutral [{Au(TSC)}2 ] species were obtained from one of the compounds in dichlomethane/n-hexane solution and characterized by X-ray crystallography revealing a Au-Au bond, and deprotonated thiosemicarbazone (TSC). The cytotoxicity of the gold compounds and thiosemicarbazone ligands was evaluated against selected cancer cell lines and compared to that of Auranofin. Studies of the most stable, cytotoxic, and selective compound on a renal cancer cell line (Caki-1) demonstrated its relevant antimigratory and anti-angiogenic properties, and preferential accumulation in the cell nuclei. Its mode of action seems to involve interaction with DNA, and subsequent cell death via apoptosis.

Cited by
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Journal ArticleDOI
TL;DR: In this article, the authors summarize literature data on thermal decomposition of ammonium perchlorate and discuss the mechanism of the decomposition and various factors that influence the thermal decompositions of perchlorates.

492 citations

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TL;DR: In this article, the current knowledge of topochemical reactions and their characteristic features is reviewed, and questions referring to the refinement of terminology and definition of the topochemical processes are discussed.

42 citations

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TL;DR: In this article, the authors systematically consider the factors responsible for localization and autolocalization of thermal decomposition processes of solids and show the specificity and complexity of nucleation and nuclei growth in topochemical processes.

29 citations

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TL;DR: In this paper, the authors deal with some of the assumtions and limitations of classical models used in thermal analysis kinetic studies of solid-state rections, and propose a new model based on non-classical models.
Abstract: The paper deals with some of the assumtions and limitations of ‘classical’ models used in thermal analysis kinetic studies of solid-state rections.

22 citations

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TL;DR: A review of studies of reactivities of solids is presented in this article, concentrating on localization and autolocalization phenomena, and some examples of feed-back and structure of the reaction zone are given.
Abstract: A review of studies of reactivities of solids is presented, concentrating on localization and autolocalization phenomena. Some examples of feed-back and structure of the reaction zone are given.

4 citations