E. Götschi

Bio: E. Götschi is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 252 citations.

Sulfidkontraktion via alkylative Kupplung: Eine methode zur darstellung von β‐dicarbonylderivaten. Über synthetische methoden, 1. Mitteilung

Abstract: The experiments described in reaction schemes 1–12 indicate that sulfide contraction via alkylative coupling (see scheme p. 729) is a potentially general method for the synthesis of secondary vinylogous amides and enolizable β-dicarbonyl compounds.

Amide activation: an emerging tool for chemoselective synthesis

Abstract: It is textbook knowledge that carboxamides benefit from increased stabilisation of the electrophilic carbonyl carbon when compared to other carbonyl and carboxyl derivatives This results in a considerably reduced reactivity towards nucleophiles Accordingly, a perception has been developed of amides as significantly less useful functional handles than their ester and acid chloride counterparts However, a significant body of research on the selective activation of amides to achieve powerful transformations under mild conditions has emerged over the past decades This review article aims at placing electrophilic amide activation in both a historical context and in that of natural product synthesis, highlighting the synthetic applications and the potential of this approach