A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

Compounds and methods for the treatment or prevention of flavivirus infections

Factors and Mechanisms that Influence the Reactivity of Trivalent Copper: A Novel Oxidant for Selective Degradation of Antibiotics

Cp* Iridium Precatalysts for Selective C- H Oxidation with Sodium Periodate As the Terminal Oxidant

Iron-Catalyzed Generation of α-Amino Nitriles from Tertiary Amines

Thermodynamic measurements were made for the binary mixture of water + γ-valerolactone (GVL) and for pure GVL to facilitate the development of the technology of lignin removal from lignocellulosic biomass (Fang, W.; Sixta, H. Advanced Biorefinery based on the Fractionation of Biomass in γ - Valerolactone and Water. ChemSusChem 2015, 8, 73−76). The density and vapor pressure of pure GVL as a function of temperature were measured and correlated for a wide range of the temperatures and pressures. Isothermal vapor–liquid equilibrium (VLE) data of the binary mixture of water + GVL were measured at 350.2 K with a static total pressure apparatus. Absence of an azeotrope was confirmed by circulation still measurements with diluted GVL solutions. Excess molar enthalpy (hE) of the mixture for the whole range of mole fractions including infinite dilution was measured using a SETARAM C80 calorimeter equipped with a flow mixing cell at 322.6 and 303.2 K. The VLE and hE data were used for the optimization of UNIQUAC an...

Vapor–Liquid Equilibria, Excess Enthalpy, and Density of Aqueous γ-Valerolactone Solutions.

1.

The azacycloalkanes HNCH2(CH2)nCH2CH2 (n=1–3), on treatment with the Na2S2O8-NaCN-NaOH system, undergo the competing reactions of N-cyanation to give the ureas, C-cyanation to give 2-cyanoazacycloalkanes, and β-fragmentation to give N-cyanomethyl- and N-formylazacycloalkanes. The relative proportions of these three competing reactions depend on the size of the ring.




2.

Oxidative β-fragmentation of azacycloalkanes also occurs in the K3Fe(CN)6-NaOH and Na2S2O8-AgNO3-NaOH systems.

Oxidation of azacycloalkanes

1.

During the oxidative cyanation of 2-, 3-, and 4-methylcyclohexanones in the Na2S2O8-NaCN system the corresponding 4-cyano(methyl)cyclohexanones are formed regiospecifically.




2.

The oxidative cyanation of 2- and 3-methylcyclohexanones takes place diastereoselectively with the formation of trans- and cis-4-cyano-2(3)-methylcyclohexanones in a ratio of 1.5∶1 (or 2∶1). The selectivity of cyanation is determined by the bridge structure of the intermediate 4-oxo(methyl)cyclohexyl radicals, which are the precursors of the 4-cyanocyclohexanones.

Stereochemistry of the remote oxidative cyanation of methylcyclohexanones

The homolytic heterocyclization of dialkyl- and diaryl-acetylenes with 1,2-ethanedithiol leads stereoselectively to cis-2,3-disubstituted 1,4-dithianes. The stereochemistry of the reactions is determined by a combination of homolytic trans addition at the triple bond and intramolecular homolytic cis addition at the double bond. The main product of the heterocyclization of dimethyl acetylenedicarboxylate is dimethyl 5,6-dihydro-1,4-dithiin-2,3-dicar-boxylate.

Stereochemistry of the homolytic heterocyclization of alkynes with 1,2-ethanedithol into 1,4-dithianes

A single stage remote oxidation of ketones to γ- and δ-diketones has been carried out in a sodium peroxysulfate-iron(II) sulfate system.

Remote oxidation of ketones to γ- and δ-diketones

1.

In the Na2S2O8-CuCl2 system, secondary aliphatic amines (RCH2CH2)2NH are transformed into 2-chloro- and 2,2-dichloroalkanals, alkanoic acids and their alkylamides; their most probable precursors are RCH2CH=NCH2CH2R azomethines, formed as a result of oxidative deprotonation.




2.

In the Na2S2O8-NaCN-NaOH system, oxidation of dialkylamines by a mechanism of oxidative substitution with the formation of the products of N-cyanidation: cyanamides and ureas, and the products of N-hydroxylation, dialkylhydroxylamines, predominate.

E. I. Troyanskii

Papers

Oxidation of azacycloalkanes

Stereochemistry of the remote oxidative cyanation of methylcyclohexanones

Stereochemistry of the homolytic heterocyclization of alkynes with 1,2-ethanedithol into 1,4-dithianes

Remote oxidation of ketones to γ- and δ-diketones

Oxidation of secondary aliphatic amines in systems containing sodium peroxydisulfate