A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

Compounds and methods for the treatment or prevention of flavivirus infections

Factors and Mechanisms that Influence the Reactivity of Trivalent Copper: A Novel Oxidant for Selective Degradation of Antibiotics

Cp* Iridium Precatalysts for Selective C- H Oxidation with Sodium Periodate As the Terminal Oxidant

Iron-Catalyzed Generation of α-Amino Nitriles from Tertiary Amines

Thermodynamic measurements were made for the binary mixture of water + γ-valerolactone (GVL) and for pure GVL to facilitate the development of the technology of lignin removal from lignocellulosic biomass (Fang, W.; Sixta, H. Advanced Biorefinery based on the Fractionation of Biomass in γ - Valerolactone and Water. ChemSusChem 2015, 8, 73−76). The density and vapor pressure of pure GVL as a function of temperature were measured and correlated for a wide range of the temperatures and pressures. Isothermal vapor–liquid equilibrium (VLE) data of the binary mixture of water + GVL were measured at 350.2 K with a static total pressure apparatus. Absence of an azeotrope was confirmed by circulation still measurements with diluted GVL solutions. Excess molar enthalpy (hE) of the mixture for the whole range of mole fractions including infinite dilution was measured using a SETARAM C80 calorimeter equipped with a flow mixing cell at 322.6 and 303.2 K. The VLE and hE data were used for the optimization of UNIQUAC an...

Vapor–Liquid Equilibria, Excess Enthalpy, and Density of Aqueous γ-Valerolactone Solutions.

1.

Unsubstituted alkanoic acid amides R(CH2)4CONH2 (R=H or alkyl) convert in Na2S2O8-CuCl2 and Na2S2O8-NaCl oxidation systems via intermediate amidyl radicals R(CH2)4C(O)NH intoγ- and δ-lactones with a considerable predominance ofγ-lactones.




2.

Monoalkyl amides of alkanoic acids are lactonized to an inappreciable extent by the action of the S2O82−-Cl− system; N,N-diethyl valeramide undergoes oxidative dealkylation into N-alkyl valeramide.




3.

As the result of an oxidative, Hoffmann type rearrangement in a Na2S2O8-NaCl-NaOH system, unsubstituted alkanoic acid amides convert into amines containing one carbon atom less than the initial amides.

Reaction of amidyl radicals in sodium peroxydisulfate-metal chloride oxidation systems

1.

Oxidative cyclization of N-unsubstituted aliphatic thioamides in the Na2S2O8-CuCl2 system leads to 3,5-dialkyl-1,2,4-thiadiazoles in a yield of 50–60%.




2.

N-Monoalkyl- and N,N-dialkyl-substituted thioamides quantitatively convert in this system into the corresponding O-amides.




3.

The principal difference in the oxidative reactions of aliphatic thioamides and their oxygen analogs in a Na2S2O8-CuCl2 system is determined by the tendency of the S atom of the. thiocarbonyl group to add radicals formed in the oxidation process.

Oxidation of aliphatic thioamides in a sodium peroxydisulfate-cupric chloride system

1.

The decarboxylation of acyloxy radicals and the rearrangement of these radicals with 1,5- or 1,6-hydrogen migration are thermodynamically equivalent.




2.

Analysis of the structure of the molecular orbitals of acyloxy radicals shows that the coordination of these radicals with variable-valence metals capable of transferring electron density suppresses the decarboxylation reaction.

Theoretical examination of the competitive decarboxylation and isomerization of acyloxy radicals

1.

The oxidation of cyanohydrins by the S2O82−-Ag+ system begins with the reaction of the OH group of the cyanohydrin with silver ions, which results in the formation of 1-cyanoalkoxyl radicals. The sulfate ion-radicals practically do not take part in the direct oxidation of cyanohydrins.




2.

The initiation of the oxidation of cyanohydrins by peroxydisulfate in the absence of Ag+ ion proceeds via the cleavage of H atoms from the hydrocarbon groupings of the cyanohydrin by the sulfate ion-radicals. The 4(5)-hydroxy-4(5)-cyanoalkyl radicals, formed as a result of the 1, 4- and 1, 5-migration of the cyano group and subsequent oxidation, are converted to 5- and 6-cyanoalkanones. The oxidative rearrangement of alkanone cyanohydrins to 6-cyanoalkanones was observed for the first time.

Oxidative rearrangement of cyanohydrins with migration of cyano group: Mechanism of initiation by S2O8 2−-Ag+ system

A one-step general synthesis has been developed for the synthesis of-γ-and δ-cyano-ketones and cyanoacids, based on the remote oxidative cyanation of carbonyl compounds by the sodium peroxydisulfate-sodium cyanide system.

E. I. Troyanskii

Papers

Reaction of amidyl radicals in sodium peroxydisulfate-metal chloride oxidation systems

Oxidation of aliphatic thioamides in a sodium peroxydisulfate-cupric chloride system

Theoretical examination of the competitive decarboxylation and isomerization of acyloxy radicals

Oxidative rearrangement of cyanohydrins with migration of cyano group: Mechanism of initiation by S2O8 2−-Ag+ system

One-step remote oxidative cyanation of ketones and aldehydes