E. I. Troyanskii

Bio: E. I. Troyanskii is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Radical & Homolysis. The author has an hindex of 2, co-authored 46 publications receiving 29 citations.

Ag+-catalyzed oxidation of alkanal cyanohydrins by peroxydisulfate

Abstract: 1. Alkanal cyanohydrins (ACH) of general formula R(CH2)3CH(OH)CN are oxidized by the system S2O82−Ag+ to the acids R(CH2)3COOH and NCCHRCH2CH2COOH, indicating the competitive conversion of the ACH in the initial stage of the reaction to 1-hydroxy-1-cyanoalkyl and 1-cyanoalkoxyl radicals. 2. The oxidation of acetaldehyde cyanohydrin at 60° proceeds at approximately twice the rate of the oxidation of butanal, pentanal, isopentanal, and heptanal cyanohydrins, and approximately ten times as fast as that of tert-butanol.

Reaction of primary aliphatic amines in oxidation systems containing sodium peroxydisulfate

Abstract: 1. Primary aliphatic amines RCH2CH2NH2 are converted by the action of the Na2S2O8-CuCl2 system into nitriles RCH2CN, 2,2-dichloroalkanals RCCl2CHO, acids RCH2COOH, and chloroalkanes RCH2CH2Cl. The formation of 2, 2-dichloroalkanals and chloroalkanes are new reactions of oxidative substitution of the amino group in primary aliphatic amines. 2. A mechanism for the reactions has been proposed, including the production of aminyl radicals RCH2-CH2NH and their oxidation into aldimines RCH2CH=NH, predecessors of all the reaction products.

Oxidative cyclization of ω-carboxyalkyl radicals to lactones

Abstract: 1. ω-Carboxyalkyl radicals HOOC(CH2)nCH2, where n=4–7, were generated by the oxidative decarboxylation of pentane-, hexane-, heptane-, and octanedicarboxylic acids at 60°C in aqueous solution by the action of Na2S2O8 in the presence of silver nitrate. The relation between the ability of these radicals to undergo oxidative cyclization to lactones and the number of methylene groups (n) and also the effect of copper ions on the oxidative cyclization process were investigated. 2. The main products from oxidative cyclization ofω-carboxyalkyl radicals in the absence of copper ions areγ-alkyl-γ-butyrolactones. In addition, alkanoic acids (84–95%) are formed as a result of abstraction of H atoms from the organic substrates by the radicals. 3. The main products from the oxidative cyclization of theω-carboxyalkyl radicals in the presence of copper ions areγ-alkyl-Δα,β-butenoiides.ω-Alkenoic acids (58–98%) are formed as a result of the oxidativeβ-deprotonation of the radicals by the action of Cu(II).

Quantum-chemical analysis of the factors affecting the stabilization of acyloxyl radicals in oxidizing systems

Abstract: 1. It was shown on the basis of quantum-chemical analysis by the LCAO-MO SCF method in the INDO approximation that the complexation of acyloxyl radicals with copper(II) salts and also their combination with chlorine atoms are factors which lead to the stabilization of these radicals and to the possibility of the realization of reactions with retention of the carboxy1 function. 2. In the radical-cation RC(O)OH+ generated during the one-electron oxidation of carboxylic acids RCOOH the unpaired electron is concentrated mainly at the carbonyl oxygen atom, while in the acyloxyl radical RC(O)O it is delocalized at both oxygen atoms.

Compounds and methods for the treatment or prevention of flavivirus infections

Abstract: A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

Vapor–Liquid Equilibria, Excess Enthalpy, and Density of Aqueous γ-Valerolactone Solutions.

Abstract: Thermodynamic measurements were made for the binary mixture of water + γ-valerolactone (GVL) and for pure GVL to facilitate the development of the technology of lignin removal from lignocellulosic biomass (Fang, W.; Sixta, H. Advanced Biorefinery based on the Fractionation of Biomass in γ - Valerolactone and Water. ChemSusChem 2015, 8, 73−76). The density and vapor pressure of pure GVL as a function of temperature were measured and correlated for a wide range of the temperatures and pressures. Isothermal vapor–liquid equilibrium (VLE) data of the binary mixture of water + GVL were measured at 350.2 K with a static total pressure apparatus. Absence of an azeotrope was confirmed by circulation still measurements with diluted GVL solutions. Excess molar enthalpy (hE) of the mixture for the whole range of mole fractions including infinite dilution was measured using a SETARAM C80 calorimeter equipped with a flow mixing cell at 322.6 and 303.2 K. The VLE and hE data were used for the optimization of UNIQUAC an...