E. I. Troyanskii

Bio: E. I. Troyanskii is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Radical & Homolysis. The author has an hindex of 2, co-authored 46 publications receiving 29 citations.

Regiospecific oxidation of alkanesulfonamides to 3-oxoalkanesulfonamides

Abstract: 1. N-nonsubstituted alkanesulfonamides under the action of Na2S2O8-AgNO3-CuSO4 are transformed into 3-oxoalkanesulfonamides by regiospecific γ-oxidation with yields of 90–100% based on consumed substrate. 2. The reaction mechanism includes generation of nitrogen-centered sulfonylamidyl radicals and rearrangement with 1,5-hydrogen migration to carbon centered radicals as recorded by EPR. The regiospecificity of the 1,5-hydrogen migration is determined probably by complex formation of the sulfonylamidyl radicals with silver ions.

Oxidation of primary amines by potassium ferricyanide

Abstract: 1. By the action of the K3Fe(CN)6-NaOH system, primary alkylamines RCH2NH2 are oxidized into alkanoic acid nitriles RCN. The action of the K3Fe(CN)6-NaOH system on heptylamine also leads to its N-cyanation with the formation of N-heptylurea, which is readily hydrolyzed under the reaction conditions. 2. By the action of the K3Fe(CN)6-NaOH system, primary sec-alkylamines R,R'CHNH2 convert into alkylhydrazones of alkanones RR'C=N-NHCHRR' as the result of oxidative dimerization.

Heterocyclization of derivatives of thioncarboxylic acids to 1,3,4-thiadiazoles under the action of tert-butyl hypochlorite

Abstract: A method for synthesis of 2-alkyl-5-aryl- and 2,5-diaryl-1,3,4-thiadiazoles by successive reaction of thioamides with tert-butyl hypochlorite and benzothiohydrazides was developed. The first step in the formation of 1,3,4-thiadiazoles consists of oxidation of thioamides with tert-butyl hypochlorite with O atom transfer to the S atom, which was established by transformation of N-methyl-thiobutanamide into N-(methylimino)butanesulfenic acid.

The synthesis of spirane and bicyclic thiolanes from homoallylic thiols

Abstract: 3-Alkenethiols are readily cyclized upon thermal or homolytic initiation with the formation of the corresponding tetrahydrothiophenes (thiolanes) [1,2]o We have found that this reaction may serve as an efficient method for the synthesis of bicyclic thiolanes (IV) and previously unreported spirothiolanes (II). Homoallyl mercaptans (I) obtained by the alkylborylation of thioketones [3] in the presence of the Pr3B-O2-CH3OH system used to generate thiyl radicals from mercaptans [4,5] cyclize to give spirothiolanes (II). The experimental procedure was analogous to that given in our previous work [5].

Compounds and methods for the treatment or prevention of flavivirus infections

Abstract: A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

Vapor–Liquid Equilibria, Excess Enthalpy, and Density of Aqueous γ-Valerolactone Solutions.

Abstract: Thermodynamic measurements were made for the binary mixture of water + γ-valerolactone (GVL) and for pure GVL to facilitate the development of the technology of lignin removal from lignocellulosic biomass (Fang, W.; Sixta, H. Advanced Biorefinery based on the Fractionation of Biomass in γ - Valerolactone and Water. ChemSusChem 2015, 8, 73−76). The density and vapor pressure of pure GVL as a function of temperature were measured and correlated for a wide range of the temperatures and pressures. Isothermal vapor–liquid equilibrium (VLE) data of the binary mixture of water + GVL were measured at 350.2 K with a static total pressure apparatus. Absence of an azeotrope was confirmed by circulation still measurements with diluted GVL solutions. Excess molar enthalpy (hE) of the mixture for the whole range of mole fractions including infinite dilution was measured using a SETARAM C80 calorimeter equipped with a flow mixing cell at 322.6 and 303.2 K. The VLE and hE data were used for the optimization of UNIQUAC an...