Author
E M Isin
Bio: E M Isin is an academic researcher. The author has co-authored 1 publications.
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TL;DR: The challenges and opportunities in the field of biotransformation were presented and discussed at the 1st European Biotransformation workshop which was conducted virtually in collaboration with the DMDG 27 January 2021 as mentioned in this paper.
Abstract: 1. Challenges and opportunities in the field of biotransformation were presented and discussed at the 1st European Biotransformation workshop which was conducted virtually in collaboration with the DMDG 27 January 2021. Here we summarize the presentations and discussions from this workshop.The following topics were covered:2. Needs for radiolabel for IND filing versus quantitation without standards.3. Applications of cyclic ion mobility in the field of biotransformation.4. Computational predictions of xenobiotic metabolism.5. Future (outsourcing) needs in biotransformation.6. Genotoxicity risk assessment of metabolites and qualification of impurities using metabolite data.7. Regulatory aspects of MIST.
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TL;DR: Taylor et al. as discussed by the authors presented a study on early oncology DMPK in the early stage of cancer using a clinical trial at the University of London's Department of Metabolism, Digestion and Reproduction.
Abstract: Simon Taylor , Jamie Henshall, Kevin Beaumont, Steve Hood , Barry Jones, Ian Wilson and Dennis Smith Pharmaron UK, Hoddesdon, UK; Development Science, UCB Biopharma SRL, Slough, UK; Early Oncology DMPK, Astrazeneca, Little Chesterford, UK; GSK Medicines Research Centre, Stevenage, UK; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK; Independent, Walmer, UK