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Author

E. V. Nurieva

Bio: E. V. Nurieva is an academic researcher from Moscow State University. The author has contributed to research in topics: Adamantane & Nonane. The author has an hindex of 9, co-authored 49 publications receiving 298 citations.
Topics: Adamantane, Nonane, Bicyclic molecule, Moiety, Tubulin


Papers
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Journal ArticleDOI
TL;DR: The review describes the syntheses and probable biologically active conformations of taxol, a natural antitumor agent, and systematizes published data on the structure-activity relations in the series ofTaxol analogs.
Abstract: The review describes the syntheses and probable biologically active conformations of taxol, a natural antitumor agent, and systematizes published data on the structure-activity relations in the series of taxol analogs.

36 citations

Journal ArticleDOI
TL;DR: A series of analogues of conjugate 1, combining an adamantane-based paclitaxel (taxol) mimetic with colchicine was synthesized and tested for cytotoxicity in a cell-based assay with the human lung carcinoma cell line A549 as discussed by the authors.

27 citations

Journal ArticleDOI
TL;DR: In this paper, a new approach to the regioselective synthesis of polyfunctional 3H-pyrroles from 4-oxoalkane-1,1,2,2-tetracarbonitriles is described.

26 citations

Journal ArticleDOI
TL;DR: The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α-tubulin subunit.
Abstract: Highly cytotoxic C7-modified colchicine analogues, exemplified by tubuloclustin, promote microtubule disassembly followed by the formation of very stable tubulin clusters, both in vitro and in cells. The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α-tubulin subunit.

23 citations

Journal ArticleDOI
TL;DR: Several adamantane-based taxol mimetics were synthesized and found to be cytotoxic at micromolar concentrations and to cause tubulin aggregation and to possess both microtubule depolymerizing and micro Tubulin bundling activities in A549 human lung carcinoma cells.

23 citations


Cited by
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Journal ArticleDOI
TL;DR: The perspective taken herein will allow C-H oxidation reactions to be more readily incorporated into synthetic planning and to emphasize chemoselectivity imposed by the nature of the substrate.
Abstract: C-H oxidation has a long history and an ongoing presence in research at the forefront of chemistry and interrelated fields. As such, numerous highly useful articles and reviews have been written on this subject. Logically, these are generally written from the perspective of the scope and limitations of the reagents employed. This Minireview instead attempts to emphasize chemoselectivity imposed by the nature of the substrate. Consequently, many landmark discoveries in the field of C-H oxidation are not discussed, but hopefully the perspective taken herein will allow C-H oxidation reactions to be more readily incorporated into synthetic planning.

1,070 citations

Journal ArticleDOI
TL;DR: A detailed account of the design strategies employed for the synthesis of anticancer agents via molecular hybridization techniques is offered and the structure activity relationship along with mechanistic insights revealed during the biological evaluation of the hybrids are highlighted.

308 citations

Journal ArticleDOI
TL;DR: This review takes an overview of the literature for the synthesis of oxetane derivatives, concentrating on advances in the last five years up to the end of 2015, clustered by strategies for preparation of the ring and further derivatization of preformedOxetane-containing building blocks.
Abstract: The four-membered oxetane ring has been increasingly exploited for its contrasting behaviors: its influence on physicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-opening reactions as a synthetic intermediate. These applications have driven numerous studies into the synthesis of new oxetane derivatives. This review takes an overview of the literature for the synthesis of oxetane derivatives, concentrating on advances in the last five years up to the end of 2015. These methods are clustered by strategies for preparation of the ring and further derivatization of preformed oxetane-containing building blocks. Examples of the use of oxetanes in medicinal chemistry are reported, including a collation of oxetane derivatives appearing in recent patents for medicinal chemistry applications. Finally, examples of oxetane derivatives in ring-opening and ring-expansion reactions are described.

281 citations

Journal ArticleDOI
TL;DR: The C-H-Oxidation as mentioned in this paper is eine lange Geschichte und ist seit jeher Teil der Spitzenforschung in der Chemie and verwandten Gebieten.
Abstract: Die C-H-Oxidation hat eine lange Geschichte und ist seit jeher Teil der Spitzenforschung in der Chemie und verwandten Gebieten. Folgerichtig wurde bereits eine grose Zahl sehr nutzlicher Originalbeitrage und Ubersichten zu diesem Thema veroffentlicht. Logischerweise wurden diese Artikel im Allgemeinen mit Blick auf die Anwendungsmoglichkeiten und Grenzen der verwendeten Reagentien geschrieben. Ziel dieses Kurzaufsatzes ist es hingegen, stattdessen die durch die Eigenschaften der Substrate hervorgerufene Chemoselektivitat herauszuarbeiten. Dies bringt es mit sich, dass viele bahnbrechende Entdeckungen auf dem Gebiet der C-H-Oxidationen nicht behandelt werden; die hier eingenommene Sichtweise wird aber hoffentlich eine schnellere Aufnahme von C-H-Oxidationsreaktionen in Syntheseplanungen ermoglichen.

268 citations

Journal ArticleDOI
Joe Liu1, Daniel Obando1, Vivian Wan Yu Liao1, Tulip Lifa1, Rachel Codd1 
TL;DR: The hydrophobic substituent constant for the adamantyl group has been estimated from the calculated partition coefficients (clogP values) of 31 adamantyl-bearing compounds in the clinic or in development as πadamantyl=3.1, which indicates that the logP value of a compound with high water solubility could be moved with an adamanty-based modification to a region that is more clinically useful.

227 citations