E
Earl R. Stadtman
Researcher at National Institutes of Health
Publications - 229
Citations - 46879
Earl R. Stadtman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Glutamine synthetase & Adenylylation. The author has an hindex of 96, co-authored 229 publications receiving 45293 citations.
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Book ChapterDOI
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
Journal ArticleDOI
Protein Oxidation in Aging, Disease, and Oxidative Stress
Journal ArticleDOI
Protein oxidation and aging
TL;DR: The importance of protein oxidation in aging is supported by the observation that levels of oxidized proteins increase with animal age and may reflect age-related increases in rates of ROS generation, decreases in antioxidant activities, or losses in the capacity to degrade oxidized protein.
Journal ArticleDOI
Free radical-mediated oxidation of free amino acids and amino acid residues in proteins.
TL;DR: It is evident that the cyclic oxidation and reduction of the sulfur-containing amino acids may serve as an important antioxidant mechanism, and also that these reversible oxidations may provide an important mechanism for the regulation of some enzyme functions.
Journal ArticleDOI
Protein oxidation and aging
TL;DR: The importance of protein oxidation in aging is supported by the observation that levels of oxidized proteins increase with animal age and may reflect age-related increases in rates of ROS generation, decreases in antioxidant activities, or losses in the capacity to degrade oxidized protein.