E
Eckart D. Gundelfinger
Researcher at Leibniz Institute for Neurobiology
Publications - 290
Citations - 23857
Eckart D. Gundelfinger is an academic researcher from Leibniz Institute for Neurobiology. The author has contributed to research in topics: Postsynaptic density & Active zone. The author has an hindex of 83, co-authored 280 publications receiving 22033 citations. Previous affiliations of Eckart D. Gundelfinger include University of Ulm & University of California, Los Angeles.
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Journal ArticleDOI
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors.
Gabriele Grenningloh,Axel Rienitz,Bertram Schmitt,Christoph Methfessel,Christoph Methfessel,Monika Zensen,Monika Zensen,Konrad Beyreuther,Konrad Beyreuther,Eckart D. Gundelfinger,Heinrich Betz +10 more
TL;DR: The deduced polypeptide shows significant structural and amino-acid sequence homology with nicotinic acetylcholine receptor proteins, indicating that there is a family of genes encoding neurotransmitter-gated ion channels.
Journal ArticleDOI
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Michael J. Schmeisser,Elodie Ey,Stephanie Wegener,Juergen Bockmann,A. Vanessa Stempel,Angelika Kuebler,Anna-Lena Janssen,Patrick T Udvardi,Ehab Shiban,Christina Spilker,Detlef Balschun,Boris V. Skryabin,Susanne tom Dieck,Karl-Heinz Smalla,Dirk Montag,Claire S. Leblond,Philippe Faure,Nicolas Torquet,Anne-Marie Le Sourd,Roberto Toro,Andreas M. Grabrucker,Sarah A. Shoichet,Dietmar Schmitz,Michael R. Kreutz,Thomas Bourgeron,Eckart D. Gundelfinger,Tobias M. Boeckers +26 more
TL;DR: It is shown that different abnormalities in synaptic glutamate receptor expression can cause alterations in social interactions and communication, and it is proposed that appropriate therapies for autism spectrum disorders are to be carefully matched to the underlying synaptopathic phenotype.
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Hair cell synaptic ribbons are essential for synchronous auditory signalling
Darina Khimich,Régis Nouvian,Régis Nouvian,Rémy Pujol,Susanne tom Dieck,Susanne tom Dieck,Alexander Egner,Eckart D. Gundelfinger,Tobias Moser +8 more
TL;DR: It is concluded that ribbon-dependent synchronous release of multiple vesicles at the hair cell afferent synapse is essential for normal hearing.
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Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity.
Renato Frischknecht,Martin Heine,Martin Heine,David Perrais,Constanze I. Seidenbecher,Daniel Choquet,Eckart D. Gundelfinger +6 more
TL;DR: The results suggest that the surface compartments formed by the ECM hinder lateral diffusion of AMPA receptors and may therefore modulate short-term synaptic plasticity.
Journal ArticleDOI
Bassoon, a Novel Zinc-finger CAG/Glutamine-repeat Protein Selectively Localized at the Active Zone of Presynaptic Nerve Terminals
Susannetom Dieck,Lydia Sanmartı́-Vila,Kristina Langnaese,Karin Richter,Stefan Kindler,Antje Soyke,Heike Wex,Karl-Heinz Smalla,Udo Kämpf,Jürgen-Theodor Fränzer,Markus Stumm,Craig C. Garner,Eckart D. Gundelfinger +12 more
TL;DR: It is shown that Bassoon, a novel protein of >400,000 M r, is a new component of the presynaptic cytoskeleton, and biochemical studies suggest a tight association with cytoskeletal structures.