Edda Cava

TL;DR: It is demonstrated in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans, and it is suggested that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.

TL;DR: It is confirmed the necessity to routinely perform nutritional status evaluation in elderly subjects, to carry out training courses for health workers and caregivers, to implement nutritional education of the geriatric population, and to identify and reduce clinical, functional, social or economic risk factors for malnutrition.

TL;DR: It is concluded that weight-loss therapy, including a hypocaloric diet with adequate (but not excessive) protein intake and increased physical activity (particularly resistance-type exercise), should be promoted to maintain muscle mass and improve muscle strength and physical function in persons with obesity.

TL;DR: Accumulating data indicate that moderate CR with adequate nutrition has a powerful protective effect against obesity, type 2 diabetes, inflammation, hypertension, cardiovascular disease and reduces metabolic risk factors associated with cancer.

TL;DR: The data indicate that CR in humans is associated with sustained rises in serum cortisol, reduced inflammation, and increases in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles.