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Edda De Rossi
Researcher at University of Pavia
Publications - 44
Citations - 3050
Edda De Rossi is an academic researcher from University of Pavia. The author has contributed to research in topics: Efflux & Mycobacterium smegmatis. The author has an hindex of 22, co-authored 44 publications receiving 2752 citations. Previous affiliations of Edda De Rossi include University of Cagliari.
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Journal ArticleDOI
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov,Giulia Manina,Katarína Mikušová,Ute Möllmann,O. B. Ryabova,Brigitte Saint-Joanis,Neeraj Dhar,Maria Rosalia Pasca,Silvia Buroni,Anna Paola Lucarelli,Anna Milano,Edda De Rossi,Martina Belanova,Adela Bobovská,Petronela Dianišková,Jana Korduláková,Claudia Sala,Elizabeth Fullam,Patricia Schneider,John D. McKinney,Priscille Brodin,Thierry Christophe,Simon J. Waddell,Philip D. Butcher,Jakob Albrethsen,Ida Rosenkrands,Roland Brosch,Vrinda Nandi,Sowmya Bharath,Sheshagiri Gaonkar,Radha Shandil,V. Balasubramanian,Tanjore S. Balganesh,Sandeep Tyagi,Jacques H. Grosset,Giovanna Riccardi,Stewart T. Cole +36 more
TL;DR: The synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB are described.
Journal ArticleDOI
Role of mycobacterial efflux transporters in drug resistance: an unresolved question
TL;DR: This review highlights recent advances in the understanding of efflux-mediated drug resistance in mycobacteria, including the distribution of Efflux systems in these organisms, their substrate profiles and their contribution to drug resistance.
Journal ArticleDOI
MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212
Valentina La Rosa,Giovanna Poce,Julio Ortiz Canseco,Silvia Buroni,Maria Rosalia Pasca,Mariangela Biava,Ravikiran M. Raju,Giulio Cesare Porretta,S. Alfonso,Claudio Battilocchio,Babak Javid,Flavia Sorrentino,Thomas R. Ioerger,James C. Sacchettini,Fabrizio Manetti,Maurizio Botta,Alessandro De Logu,Eric J. Rubin,Edda De Rossi +18 more
TL;DR: The screening of genomic libraries and whole-genome sequencing found that all the characterized mutants showed mutations in the mmpL3 gene, allowing us to conclude that resistance to BM212 maps to the MMPL3 protein, a member of the MmpL (mycobacterial membrane protein, large) family.
Journal ArticleDOI
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis.
João Neres,Florence Pojer,Elisabetta Molteni,Laurent R. Chiarelli,Neeraj Dhar,Stefanie Boy-Röttger,Silvia Buroni,Elizabeth Fullam,Giulia Degiacomi,Anna Paola Lucarelli,Randy J. Read,Giuseppe Zanoni,Dale E. Edmondson,Edda De Rossi,Maria Rosalia Pasca,John D. McKinney,Paul J. Dyson,Giovanna Riccardi,Andrea Mattevi,Stewart T. Cole,Claudia Binda +20 more
TL;DR: The crystal structure of the mycobacterial DprE1 reveals how the TB drug benzothiazinone BTZ043 blocks this microbial enzyme target, and structural and kinetic analysis provides both insight into a critical epimerization reaction and a platform for structure-based design of improved inhibitors.
Journal ArticleDOI
Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis
Maria Rosalia Pasca,Paola Guglierame,Fabio Arcesi,Marco Bellinzoni,Edda De Rossi,Giovanna Riccardi +5 more
TL;DR: The Mycobacterium tuberculosis Rv2686c-Rv2687c-rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxACin, moxifloxacIn, and sparfloxAcin to Myc Cobacterium smegmatis.