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Edgar Haber
Researcher at Harvard University
Publications - 407
Citations - 30764
Edgar Haber is an academic researcher from Harvard University. The author has contributed to research in topics: Antibody & Renin–angiotensin system. The author has an hindex of 86, co-authored 407 publications receiving 30466 citations. Previous affiliations of Edgar Haber include French Institute of Health and Medical Research & Vassar College.
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Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.
James S. Huston,D. Levinson,Meredith Mudgett-Hunter,M S Tai,Jirí Novotný,Michael N. Margolies,R J Ridge,Robert E. Bruccoleri,Edgar Haber,R Crea +9 more
TL;DR: A biosynthetic antibody binding site, which incorporated the variable domains of anti-digoxin monoclonal antibody 26-10 in a single polypeptide chain, was produced in Escherichia coli by protein engineering.
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Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects
TL;DR: Renin activity increased with Na restriction, was significantly higher on upright activity during both normal and restricted Na intake, and was most markedly elevated following the diuretic.
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Binding of immunogenic peptides to Ia histocompatibility molecules
TL;DR: A physical association of this peptide responsible for T-cell recognition of HEL is sought with purified, detergent-solubilized I–Ak molecules from B-hybridoma cells, which may explain the role of the Ia glycoproteins in cellular interactions.
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The kinetics of formation of native ribonuclease during oxidation of the reduced polypeptide chain
TL;DR: There existed a considerable lag phase before enzymatic activity appeared after the sample of bovine pancreatic ribonuclease was treated with mercaptoethanol in urea, during which period the sulfhydrl titer and the specific optical rotation changed along a curve similar to that of a first-order reaction.
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Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis
Jer-Chia Tsai,Mark A. Perrella,Masao Yoshizumi,Chung-Ming Hsieh,Edgar Haber,Robert Schlegel,Mu-En Lee +6 more
TL;DR: The growth-promoting effect of homocysteine on vascular smooth muscle cells, together with its inhibitory effect on endothelial cell growth, represents an important mechanism to explain homocy steine-induced atherosclerosis.