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Edmond Differding
Researcher at Novartis
Publications - 11
Citations - 524
Edmond Differding is an academic researcher from Novartis. The author has contributed to research in topics: Haloketone & Reagent. The author has an hindex of 6, co-authored 11 publications receiving 513 citations.
Papers
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Journal ArticleDOI
New fluorinating reagents - I. The first enantioselective fluorination reaction
Edmond Differding,Robert W. Lang +1 more
TL;DR: In this article, optically pure N-fluoro sultams (−)-3 and (+)-5 are shown to have enantioselective fluorinating reagents and unprecedented enantiomeric excesses up to 70% are observed when various prochiral metal enolates are fluorinated by using these new reagents.
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New fluorinating reagents. Part II. Preparation and Synthetic Application of a Saccharin Derived N‐Fluorosultam
Edmond Differding,Robert W. Lang +1 more
TL;DR: In this paper, the synthesis of the new saccharin derived N-fluorosultam 1 was described, and a comparative study with commercially available Nfluorosulfonamides showed 1 to be a superior fluorinating reagent for the synthesis α-fluorocarbonyl compounds.
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Nucleophilic substitution versus electron transfer: 1. On the mechanism of electrophilic fluorinations
TL;DR: The reaction of a citronellic ester enolate with electrophilic fluorinating agents gives open chain fluorinated products only as discussed by the authors, indicating that free radicals are not intermediates on the path to fluorinated product.
Journal ArticleDOI
Selective mono- and difluorination of enolates
TL;DR: In this paper, the selective transformation of enolates into mono-and difluorinated carbonyl compounds can be performed in a one-pot procedure using N-F-sultam 1.
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Electrochemical reduction of nitrogen-flourine Bonds: relevance to the reactivity of electrophilic flourinating agents
TL;DR: In this paper, the cyclovoltammetric and polarographic properties of nitrogen-flourine bond containing compounds, including representative electrophilic flourinating agents, are described.