E
Edmund M. Talley
Researcher at University of Virginia
Publications - 36
Citations - 7005
Edmund M. Talley is an academic researcher from University of Virginia. The author has contributed to research in topics: Potassium channel & Membrane potential. The author has an hindex of 32, co-authored 36 publications receiving 6573 citations. Previous affiliations of Edmund M. Talley include National Institutes of Health.
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Proceedings Article
Optimizing Semantic Coherence in Topic Models
TL;DR: A novel statistical topic model based on an automated evaluation metric based on this metric that significantly improves topic quality in a large-scale document collection from the National Institutes of Health (NIH).
Journal ArticleDOI
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels.
Edmund M. Talley,Leanne L. Cribbs,Jung-Ha Lee,Asif N. Daud,Edward Perez-Reyes,Douglas A. Bayliss +5 more
TL;DR: In this paper, localized central and peripheral nervous system expression of three transcripts (α1G, α1H, and α1I) of the T-type calcium channel family (CaVT) was found.
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CNS Distribution of Members of the Two-Pore-Domain (KCNK) Potassium Channel Family
TL;DR: The differential expression of each two-pore-domain K+ channel family member likely contributes to characteristic excitability properties in distinct populations of neurons, as well as to diversity in their susceptibility to modulation.
Journal ArticleDOI
TASK-1, a Two–Pore Domain K+ Channel, Is Modulated by Multiple Neurotransmitters in Motoneurons
TL;DR: It is shown that TASK-1, a two pore domain K+ channel, provides a prominent leak K+ current and target for neurotransmitter modulation in hypoglossal motoneurons (HMs) and also likely supports this action in other CNS neurons.
Journal ArticleDOI
Distribution of α2C‐adrenergic receptor‐like immunoreactivity in the rat central nervous system
Diane L. Rosin,Edmund M. Talley,Amy S. Lee,Ruth L. Stornetta,Bruce D. Gaylinn,Patrice G. Guyenet,Kevin R. Lynch +6 more
TL;DR: The distribution of α2C‐adrenergic receptors (ARs) in rat brain and spinal cord was examined immunohistochemically by using an affinity purified polyclonal antibody against a recombinant fusion protein consisting of a 70‐amino‐acid polypeptide portion of the third intracellular loop of the α1‐AR fused to glutathione‐S‐transferase.