E
Edward H. Cohen
Publications - 10
Citations - 663
Edward H. Cohen is an academic researcher. The author has contributed to research in topics: Serum albumin & Phage display. The author has an hindex of 5, co-authored 10 publications receiving 643 citations.
Papers
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Journal ArticleDOI
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
Rene Hoet,Edward H. Cohen,Rachel Baribault Kent,Kristin L. Rookey,Sonia Schoonbroodt,Shannon Hogan,Louise Rem,Nicolas Frans,Marc Daukandt,Henk Pieters,Rob van Hegelsom,Nicole Coolen-van Neer,Nastri Horacio G,Isaac J. Rondon,Jennifer A. Leeds,Simon E. Hufton,Lili Huang,Irina Kashin,Mary Devlin,Guannan Kuang,Mieke Steukers,Malini Viswanathan,Andrew E. Nixon,Daniel J. Sexton,Hennie R. Hoogenboom,Robert Charles Ladner +25 more
TL;DR: The construction of human Fab libraries having a unique combination of immunoglobulin sequences captured from human donors and synthetic diversity in key antigen contact sites in heavy-chain complementarity-determining regions 1 and 2 are reported.
Patent
Serum albumin binding moieties
TL;DR: In this article, compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum bandit molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to albumin.
Journal ArticleDOI
Development of mammalian serum albumin affinity purification media by peptide phage display.
Aaron K. Sato,Daniel J. Sexton,Lee A. Morganelli,Edward H. Cohen,Qi Long Wu,Greg Conley,Zoya Streltsova,Stan W. Lee,Mary Devlin,Daniel B. DeOliveira,Jasmin Enright,Rachel Baribault Kent,Charles R. Wescott,Tom C. Ransohoff,Arthur C. Ley,Robert Charles Ladner +15 more
TL;DR: Several phage isolates that bind specifically to human serum albumin were isolated from disulfide‐constrained cyclic peptide phage‐display libraries and one of the highest affinity peptides, DX‐236, also bound well to several mammalian serum albumins (SA).
Patent
Novel methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
Robert Charles Ladner,Edward H. Cohen,Nastri Horacio G,Kristin L. Rookey,Rene Hoet,Hendricus R. J. M. Hoogenboom +5 more
TL;DR: In this paper, the authors present methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods.
Patent
Conformation specific antibodies
TL;DR: In this article, the binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g. relative to a non-activated conformation of LFA-1, are disclosed.