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Edward V. Zegarelli

Bio: Edward V. Zegarelli is an academic researcher from Columbia University. The author has contributed to research in topics: Triamcinolone acetonide & Stomatitis. The author has an hindex of 17, co-authored 92 publications receiving 991 citations. Previous affiliations of Edward V. Zegarelli include NewYork–Presbyterian Hospital & Institute of Cancer Research.


Papers
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TL;DR: An examination of the composition of the separately collected parotid and submaxillary secretions affords a convenient means of studying exocrine gland function in cystic fibrosis of the pancreas.
Abstract: A COMPREHENSIVE examination of the composition of the separately collected parotid and submaxillary secretions affords a convenient means of studying exocrine gland function in cystic fibrosis of the pancreas. Deviations in composition could arise from alterations in gland structure (hypertrophy, hyperplasia), function (metabolism, protein synthesis, ion transport, cell permeability), neural regulation, or combinations thereof. Elucidation of the aberrant mechanisms responsible for salivary gland abnormality could provide meaningful clues to the basic pathogenesis of cystic fibrosis. Studies on parotid saliva have yielded conflicting results. Several investigators have reported elevations in sodium, chloride, and flow rate in cystic fibrosis patients.1-5Previous reports from this laboratory on parotid saliva indicated that although "there was a tendency for electrolyte values to be higher in a group of patients with cystic fibrosis of the pancreas, only in the case of inorganic phosphorus, however, was this elevation statistically significant."6Parotid glycoproteins were not found

99 citations

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TL;DR: Twenty-eight cases of intraoral pemphigus vulgaris are presented, all had histologic confirmation, including twenty-six from intraoral biopsies, and detailed descriptions involving many clinical features are reported and discussed.

48 citations

Journal ArticleDOI
TL;DR: A new vehicle for the application of therapeutic agents to the oral mucous membranes is described and potential usefulness of this material as a vehicle for topical oral medications and mechanical protection in the oral cavity is indicated.

46 citations


Cited by
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TL;DR: Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.
Abstract: This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

843 citations

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TL;DR: The present studies provide additional support to the idea that enamel matrix proteins are involved in the formation of acellular cementum and also that they have the potential to induce regeneration of the same type of cementum.
Abstract: Studies during the last 20 years have indicated that enamel-related proteins are involved in the formation of cementum. In the present article, this relation is further explored. Attention is called to the fact that coronal acellular extrinsic fiber cementum is formed on the enamel surface in a number of species. The composition of the enamel matrix proteins and the expression of these proteins during root formation are briefly reviewed. The dominating constituent of the enamel matrix, amelogenin, is shown by means of immunohistochemistry to be expressed in human teeth during root formation. Amelogenin was also found to be present in Tomes' granular layer of human teeth. When mesenchymal cells of the dental follicle were exposed to the enamel matrix a non-cellular hard tissue matrix was formed at the enamel surface. Application of porcine enamel matrix in experimental cavities in the roots of incisors of monkeys induced formation of acellular cementum that was well attached to the dentin. In control cavities without enamel matrix, a cellular, poorly attached hard tissue was formed. The present studies provide additional support to the idea that enamel matrix proteins are involved in the formation of acellular cementum and also that they have the potential to induce regeneration of the same type of cementum.

711 citations

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TL;DR: Saliva has the potential to become a first-line diagnostic sample of choice owing to the advancements in detection technologies coupled with combinations of biomolecules with clinical relevance as mentioned in this paper, however, these technologies have not yet been integrated into current clinical practice and work flow.
Abstract: BACKGROUND: Over the past 10 years, the use of saliva as a diagnostic fluid has gained attention and has become a translational research success story. Some of the current nanotechnologies have been demonstrated to have the analytical sensitivity required for the use of saliva as a diagnostic medium to detect and predict disease progression. However, these technologies have not yet been integrated into current clinical practice and work flow. CONTENT: As a diagnostic fluid, saliva offers advantages over serum because it can be collected noninvasively by individuals with modest training, and it offers a cost-effective approach for the screening of large populations. Gland-specific saliva can also be used for diagnosis of pathology specific to one of the major salivary glands. There is minimal risk of contracting infections during saliva collection, and saliva can be used in clinically challenging situations, such as obtaining samples from children or handicapped or anxious patients, in whom blood sampling could be a difficult act to perform. In this review we highlight the production of and secretion of saliva, the salivary proteome, transportation of biomolecules from blood capillaries to salivary glands, and the diagnostic potential of saliva for use in detection of cardiovascular disease and oral and breast cancers. We also highlight the barriers to application of saliva testing and its advancement in clinical settings. SUMMARY: Saliva has the potential to become a first-line diagnostic sample of choice owing to the advancements in detection technologies coupled with combinations of biomolecules with clinical relevance.

621 citations

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TL;DR: In the first volume of the Journal of Oral Surgery, Dr G. Victor Boyko presented a case of osteofibroma of the mandible associated with leontiasis ossea of the skull, with evidence of both bone destruction and proliferation in the inferior frontal and orbital regions.

537 citations

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TL;DR: Of the many immunological changes described in LP several may be epiphenomena although a cell-mediated immune response to unidentified antigens or antigenic changes clearly is involved.
Abstract: Lichen planus (LP) is a common oral disorder which may represent the manifestation of a mucosal reaction to a variety of aetiological factors. Of the many immunological changes described in LP several may be epiphenomena although a cell-mediated immune response to unidentified antigens or antigenic changes clearly is involved. Associations with drugs or systemic disorders are well-defined in some patients but may, in others, be aleatoric. Finally, the prognosis of oral LP not only differs from that of cutaneous LP but there is little doubt that in a few instances LP is a premalignant condition.

406 citations